OBJECTIVE: Motor cortex stimulation therapy (MCS) is increasingly used to control refractory neuropathic pain. Post-movement beta synchronization (PMBS) is defined as a sharp increase in beta-frequency electroencephalographic power following movement offset and may reflect sensorimotor cortex inhibition induced, at least in part, by cortical processing of movement-related sensory afferent inputs. PMBS pattern is then often altered in case of neuropathic pain. The main objective of the present study was to test the hypothesis that implanted MCS modulates PMBS in patients presenting with neuropathic pain. METHODS: Using a high-resolution, 128-electrode electroencephalographic system, we recorded and compared, before and during MCS, PMBS patterns during brisk, unilateral right and left index finger extension in 8 patients presenting with neuropathic pain. RESULTS: The pre-operative PMBS patterns were altered in all cases. MCS increased the spatial distribution and amplitude of PMBS in most of cases and restored maximum-intensity of PMBS contralateral to the painful body side. These modifications appeared significantly correlated with the analgesic effect of MCS. CONCLUSION: This study provides evidence of central beta rhythms neuromodulation induced by MCS. SIGNIFICANCE: The restoration by MCS of defective cortical inhibition in patients with neuropathic pain is evoked.
OBJECTIVE: Motor cortex stimulation therapy (MCS) is increasingly used to control refractory neuropathic pain. Post-movement beta synchronization (PMBS) is defined as a sharp increase in beta-frequency electroencephalographic power following movement offset and may reflect sensorimotor cortex inhibition induced, at least in part, by cortical processing of movement-related sensory afferent inputs. PMBS pattern is then often altered in case of neuropathic pain. The main objective of the present study was to test the hypothesis that implanted MCS modulates PMBS in patients presenting with neuropathic pain. METHODS: Using a high-resolution, 128-electrode electroencephalographic system, we recorded and compared, before and during MCS, PMBS patterns during brisk, unilateral right and left index finger extension in 8 patients presenting with neuropathic pain. RESULTS: The pre-operative PMBS patterns were altered in all cases. MCS increased the spatial distribution and amplitude of PMBS in most of cases and restored maximum-intensity of PMBS contralateral to the painful body side. These modifications appeared significantly correlated with the analgesic effect of MCS. CONCLUSION: This study provides evidence of central beta rhythms neuromodulation induced by MCS. SIGNIFICANCE: The restoration by MCS of defective cortical inhibition in patients with neuropathic pain is evoked.
Authors: Mohammad Sohail Asghar; Manuel Pedro Pereira; Mads Utke Werner; Johan Mårtensson; Henrik B W Larsson; Jørgen Berg Dahl Journal: PLoS One Date: 2015-01-23 Impact factor: 3.240
Authors: Eulália Silva dos Santos Pinheiro; Fernanda Costa de Queirós; Pedro Montoya; Cleber Luz Santos; Marion Alves do Nascimento; Clara Hikari Ito; Manuela Silva; David Barros Nunes Santos; Silvia Benevides; José Garcia Vivas Miranda; Katia Nunes Sá; Abrahão Fontes Baptista Journal: PLoS One Date: 2016-02-25 Impact factor: 3.240