| Literature DB >> 23151413 |
Robert J Young1, Ajay Gupta, Akash D Shah, Jerome J Graber, Timothy A Chan, Zhigang Zhang, Weiji Shi, Kathryn Beal, Antonio M Omuro.
Abstract
We examine the role of dynamic susceptibility contrast (DSC) magnetic resonance imaging (MRI) perfusion in differentiating pseudoprogression from progression in 20 consecutive patients with treated glioblastoma. MRI perfusion was performed, and relative cerebral blood volume (rCBV), relative peak height (rPH), and percent signal recovery (PSR) were measured. Pseudoprogression demonstrated lower median rCBV (P=.009) and rPH (P<.001), and higher PSR (P=.039) than progression. DSC MRI perfusion successfully identified pseudoprogression in patients who did not require a change in treatment despite radiographic worsening following chemoradiotherapy.Entities:
Mesh:
Year: 2012 PMID: 23151413 PMCID: PMC4755513 DOI: 10.1016/j.clinimag.2012.02.016
Source DB: PubMed Journal: Clin Imaging ISSN: 0899-7071 Impact factor: 1.605