| Literature DB >> 23151322 |
Nagarajan Sangaraiah1, Sathishkumar Murugan, Shanmugavelan Poovan, Ranganathan Raja, Ponnuswamy Alagusundaram, Venkatesan Ramakrishnan, Shanmugaiah Vellasamy.
Abstract
An elegant and efficient synthesis of hitherto novel 1,2,3-triazolyl dihydropyrimidine-2-thione hybrids has been accomplished for the first time in a green solvent viz. water. The hybrid molecules exhibit significant antibacterial activity when screened against four human pathogens viz. Streptococcus pneumonia, Staphylococcus aureus, Pseudomonas aeruginosa and Salmonella typhi. In comparison to the commercially marketed tetracycline, some of them were equally potent and a few more potent.Entities:
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Year: 2012 PMID： 23151322 DOI： 10.1016/j.ejmech.2012.10.029
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514