Literature DB >> 23150363

N-methyl-D-aspartate (NMDA)-mediated excitotoxic damage: a mouse model of acute retinal ganglion cell damage.

Roswitha Seitz1, Ernst R Tamm.   

Abstract

The animal model of N-methyl-D-aspartate (NMDA)-induced excitotoxic damage of retinal ganglion cells (RGC) is widely used to study the molecular mechanisms of RGC apoptosis and/or its prevention by neuroprotective agents. This chapter provides protocols for applying NMDA-induced excitotoxic damage to RGC of mouse eyes and for subsequent measuring of the extent of the resulting damage.

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Year:  2013        PMID： 23150363     DOI： 10.1007/978-1-62703-080-9_7

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  7 in total

1.  In Vivo Evaluation of White Matter Integrity and Anterograde Transport in Visual System After Excitotoxic Retinal Injury With Multimodal MRI and OCT.

Authors:  Leon C Ho; Bo Wang; Ian P Conner; Yolandi van der Merwe; Richard A Bilonick; Seong-Gi Kim; Ed X Wu; Ian A Sigal; Gadi Wollstein; Joel S Schuman; Kevin C Chan
Journal:  Invest Ophthalmol Vis Sci       Date:  2015-06       Impact factor: 4.799

2.  Mutated olfactomedin 1 in the interphotoreceptor matrix of the mouse retina causes functional deficits and vulnerability to light damage.

Authors:  Marcus A Koch; Bernd Rosenhammer; Walter Paper; Cornelia Volz; Barbara M Braunger; Johanna Hausberger; Herbert Jägle; Ernst R Tamm
Journal:  Histochem Cell Biol       Date:  2016-10-27       Impact factor: 4.304

Review 3.  The Intertwined Roles of Oxidative Stress and Endoplasmic Reticulum Stress in Glaucoma.

Authors:  Daire John Hurley; Caoimhe Normile; Mustapha Irnaten; Colm O'Brien
Journal:  Antioxidants (Basel)       Date:  2022-04-29

4.  Exploration of the glutamate-mediated retinal excitotoxic damage: a rat model of retinal neurodegeneration.

Authors:  Ling Gao; Qi-Jun Zheng; Li-Qian-Yu Ai; Kai-Jian Chen; Yuan-Guo Zhou; Jian Ye; Wei Liu
Journal:  Int J Ophthalmol       Date:  2018-11-18       Impact factor: 1.779

5.  Concentration-Dependent Inner Retina Layer Damage and Optic Nerve Degeneration in a NMDA Model.

Authors:  Sandra Kuehn; Cara Rodust; Gesa Stute; Pia Grotegut; Wilhelm Meißner; Sabrina Reinehr; H Burkhard Dick; Stephanie C Joachim
Journal:  J Mol Neurosci       Date:  2017-09-29       Impact factor: 3.444

6.  Preservation of vision after CaMKII-mediated protection of retinal ganglion cells.

Authors:  Xinzheng Guo; Jing Zhou; Christopher Starr; Ethan J Mohns; Yidong Li; Earnest P Chen; Yonejung Yoon; Christopher P Kellner; Kohichi Tanaka; Hongbing Wang; Wei Liu; Louis R Pasquale; Jonathan B Demb; Michael C Crair; Bo Chen
Journal:  Cell       Date:  2021-07-22       Impact factor: 66.850

7.  Norrin protects optic nerve axons from degeneration in a mouse model of glaucoma.

Authors:  Stephanie A Leopold; Ludwig F Zeilbeck; Gregor Weber; Roswitha Seitz; Michael R Bösl; Herbert Jägle; Rudolf Fuchshofer; Ernst R Tamm; Andreas Ohlmann
Journal:  Sci Rep       Date:  2017-10-27       Impact factor: 4.379
  7 in total

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