Literature DB >> 23150079

How can ethics relate to science? The case of stem cell research.

Ana Sofia Carvalho1, João Ramalho-Santos.   

Abstract

We live in an era of an important turning point in the relationship between ethics (or, more accurately, bioethics) and science, notably due to both public interest and the gradual tightening of the gap in time between scientific discoveries and ethical reflection. The current bioethics debates of emerging situations (pluripotent stem cells, gene therapy, nanotechnology) have undoubtedly contributed to this change. Today, science happens and bioethics reflects on the possibilities, considers the risks, and advances proposals, which, without being scientific, can also imprint a mark on the path of scientific development. In this article, through the narrative of stem cell research, we will try to illustrate how bringing a bioethical viewpoint to the scientific debate can become a healthy exercise in both ethics and science, especially as narratives shift, as was the case in this field due to the introduction of induced pluripotent stem cells, the advent of which is not easily dissociated from the controversies related to embryo research. We should perhaps welcome this trend as promising for the future relationship between ethics and scientific research, providing a stimulus (and not a block) to the ever-evolving scientific discourse.

Mesh:

Year:  2012        PMID: 23150079      PMCID: PMC3658189          DOI: 10.1038/ejhg.2012.232

Source DB:  PubMed          Journal:  Eur J Hum Genet        ISSN: 1018-4813            Impact factor:   4.246


  34 in total

1.  Going to the roots of the stem cell debate. The ethical problems of using embryos for research.

Authors:  D Mieth
Journal:  EMBO Rep       Date:  2000-07       Impact factor: 8.807

2.  Human embryonic stem cell and embryonic germ cell lines.

Authors:  J A Thomson; J S Odorico
Journal:  Trends Biotechnol       Date:  2000-02       Impact factor: 19.536

3.  Stem cells, embryos and cloning--unravelling the ethics of a knotty debate.

Authors:  Donald M Bruce
Journal:  J Mol Biol       Date:  2002-06-14       Impact factor: 5.469

4.  Bioethics critically reconsidered: living after foundations.

Authors:  H Tristram Engelhardt
Journal:  Theor Med Bioeth       Date:  2012-02

Review 5.  Can adult neural stem cells create new brains? Plasticity in the adult mammalian neurogenic niches: realities and expectations in the era of regenerative biology.

Authors:  Ilias Kazanis
Journal:  Neuroscientist       Date:  2011-05-02       Impact factor: 7.519

Review 6.  Human embryonic stem cell research: ethical and legal issues.

Authors:  J A Robertson
Journal:  Nat Rev Genet       Date:  2001-01       Impact factor: 53.242

7.  Reference Maps of human ES and iPS cell variation enable high-throughput characterization of pluripotent cell lines.

Authors:  Christoph Bock; Evangelos Kiskinis; Griet Verstappen; Hongcang Gu; Gabriella Boulting; Zachary D Smith; Michael Ziller; Gist F Croft; Mackenzie W Amoroso; Derek H Oakley; Andreas Gnirke; Kevin Eggan; Alexander Meissner
Journal:  Cell       Date:  2011-02-04       Impact factor: 41.582

8.  Human procreation in unchartered territory: new twists in ethical discussions.

Authors:  João Ramalho-Santos
Journal:  Hum Reprod       Date:  2011-04-05       Impact factor: 6.918

9.  Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells.

Authors:  Ryan Lister; Mattia Pelizzola; Yasuyuki S Kida; R David Hawkins; Joseph R Nery; Gary Hon; Jessica Antosiewicz-Bourget; Ronan O'Malley; Rosa Castanon; Sarit Klugman; Michael Downes; Ruth Yu; Ron Stewart; Bing Ren; James A Thomson; Ronald M Evans; Joseph R Ecker
Journal:  Nature       Date:  2011-02-02       Impact factor: 49.962

10.  Somatic coding mutations in human induced pluripotent stem cells.

Authors:  Athurva Gore; Zhe Li; Ho-Lim Fung; Jessica E Young; Suneet Agarwal; Jessica Antosiewicz-Bourget; Isabel Canto; Alessandra Giorgetti; Mason A Israel; Evangelos Kiskinis; Je-Hyuk Lee; Yuin-Han Loh; Philip D Manos; Nuria Montserrat; Athanasia D Panopoulos; Sergio Ruiz; Melissa L Wilbert; Junying Yu; Ewen F Kirkness; Juan Carlos Izpisua Belmonte; Derrick J Rossi; James A Thomson; Kevin Eggan; George Q Daley; Lawrence S B Goldstein; Kun Zhang
Journal:  Nature       Date:  2011-03-03       Impact factor: 49.962

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  4 in total

Review 1.  Regulation of Stem Cell Technology in Malaysia: Current Status and Recommendations.

Authors:  Nishakanthi Gopalan; Siti Nurani Mohd Nor; Mohd Salim Mohamed
Journal:  Sci Eng Ethics       Date:  2019-05-23       Impact factor: 3.525

2.  Mesenchymal stem/progenitor cell isolation from tooth extraction sockets.

Authors:  R Nakajima; M Ono; E S Hara; Y Oida; S Shinkawa; H T Pham; K Akiyama; W Sonoyama; K Maekawa; T Kuboki
Journal:  J Dent Res       Date:  2014-08-28       Impact factor: 6.116

Review 3.  Ethical considerations in the translation of regenerative biofabrication technologies into clinic and society.

Authors:  I A Otto; C C Breugem; J Malda; A L Bredenoord
Journal:  Biofabrication       Date:  2016-10-07       Impact factor: 9.954

4.  I Want More and Better Cells! - An Outreach Project about Stem Cells and Its Impact on the General Population.

Authors:  Sara Varela Amaral; Teresa Forte; João Ramalho-Santos; M Teresa Girão da Cruz
Journal:  PLoS One       Date:  2015-07-29       Impact factor: 3.240

  4 in total

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