| Literature DB >> 23150074 |
Yu-Lin Sun1, Fei He, Kai-Sheng Liu, Xiao-Yong Zhang, Jie Bao, Yi-Fei Wang, Xu-Hua Nong, Xin-Ya Xu, Shu-Hua Qi.
Abstract
Two new dihydrothiophene-condensed chromones and a new natural chromone, namely oxalicumones A-C (1-3), respectively, were isolated from a culture broth of a marine-derived fungus Penicillium oxalicum SCSGAF 0023, Meripilaceae family. The structures of 1-3 and acetylated derivatives of 1 (4-7) were elucidated on the basis of spectroscopic methods and chemical reactions. The absolute configuration of 1 was established by using the modified Mosher ester method and circular dichroism data of in situ formed [Rh₂(OCOCF₃)₄] and [Mo₂(OAc)₄] complexes. (R)-MTPA ester of 1 showed cytotoxicity against A375, SW-620, and HeLa carcinoma cell lines with IC₅₀ values of 8.9, 7.8, and 18.4 µM, respectively. Compound 1 displayed cytotoxicity against A375 and SW-620 cell lines with IC₅₀ values of 11.7 and 22.6 µM, respectively. The structure-biological activity relationship of 1 is discussed. Georg Thieme Verlag KG Stuttgart · New York.Entities:
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Year: 2012 PMID： 23150074 DOI： 10.1055/s-0032-1327874
Source DB: PubMed Journal: Planta Med ISSN： 0032-0943 Impact factor: 3.352