PURPOSE: The term diffuse parenchymal lung disease (DPLD) refers to a group of disorders affecting the lung parenchyma that can be categorized into those of known and those of unknown etiology. Early diagnosis is important since some forms of DPLD are characterized by a rapid progression to respiratory failure. Notwithstanding the fact that recently guidelines have been published, some issues concerning the practical evaluation of a patient with suspected DPLD remain unclear. METHODS: In this article we propose a practical approach to the diagnosis and differentiation of DPLD. Moreover, a critical appraisal is provided based on the current literature and frequent pitfalls are highlighted. CONCLUSION: we propose a practical workup, but in spite of increasing evidence concerning the diagnosis of DPLD, further studies will be needed to clarify several issues for efficient investigation of newly diagnosed patients with DPLD.
PURPOSE: The term diffuse parenchymal lung disease (DPLD) refers to a group of disorders affecting the lung parenchyma that can be categorized into those of known and those of unknown etiology. Early diagnosis is important since some forms of DPLD are characterized by a rapid progression to respiratory failure. Notwithstanding the fact that recently guidelines have been published, some issues concerning the practical evaluation of a patient with suspected DPLD remain unclear. METHODS: In this article we propose a practical approach to the diagnosis and differentiation of DPLD. Moreover, a critical appraisal is provided based on the current literature and frequent pitfalls are highlighted. CONCLUSION: we propose a practical workup, but in spite of increasing evidence concerning the diagnosis of DPLD, further studies will be needed to clarify several issues for efficient investigation of newly diagnosed patients with DPLD.
Authors: Shinichiro Ohshimo; Francesco Bonella; Ai Cui; Martin Beume; Nobuoki Kohno; Josune Guzman; Ulrich Costabel Journal: Am J Respir Crit Care Med Date: 2009-02-26 Impact factor: 21.405
Authors: Sonali K Sanghavi; Kareem Abu-Elmagd; Maria Cristina Keightley; Kirsten St George; Kathleen Lewandowski; Stephanie S Boes; Arlene Bullotta; Ryan Dare; Maryann Lassak; Shahid Husain; Eun J Kwak; David L Paterson; Charles R Rinaldo Journal: J Clin Virol Date: 2008-05-21 Impact factor: 3.168
Authors: Ganesh Raghu; Harold R Collard; Jim J Egan; Fernando J Martinez; Juergen Behr; Kevin K Brown; Thomas V Colby; Jean-François Cordier; Kevin R Flaherty; Joseph A Lasky; David A Lynch; Jay H Ryu; Jeffrey J Swigris; Athol U Wells; Julio Ancochea; Demosthenes Bouros; Carlos Carvalho; Ulrich Costabel; Masahito Ebina; David M Hansell; Takeshi Johkoh; Dong Soon Kim; Talmadge E King; Yasuhiro Kondoh; Jeffrey Myers; Nestor L Müller; Andrew G Nicholson; Luca Richeldi; Moisés Selman; Rosalind F Dudden; Barbara S Griss; Shandra L Protzko; Holger J Schünemann Journal: Am J Respir Crit Care Med Date: 2011-03-15 Impact factor: 21.405
Authors: Talmadge E King; Jürgen Behr; Kevin K Brown; Roland M du Bois; Lisa Lancaster; Joao A de Andrade; Gerd Stähler; Isabelle Leconte; Sébastien Roux; Ganesh Raghu Journal: Am J Respir Crit Care Med Date: 2007-09-27 Impact factor: 21.405