OBJECTIVES: To determine the incidence of vitamin D deficiency in neonates with congenital heart disease and whether differences exist by race. In addition, we determined the effect of cardiopulmonary bypass on vitamin D levels and explored associations between 25-hydroxyvitamin D [25(OH)D] levels and postoperative outcomes. STUDY DESIGN: We performed a secondary analysis of a prospective randomized controlled trial in 70 neonates undergoing cardiac surgery. The neonates' 25(OH)D levels were measured in the operating room before skin incision (baseline), at the cessation of cardiopulmonary bypass, and at 24 hours postoperatively. Associations between these levels and clinical outcomes were explored. Vitamin D deficiency was defined as a 25(OH)D level <20 ng/mL. RESULTS:Vitamin D deficiency was present in 84% (59/70); concentrations in African Americans (n = 20) were significantly lower than those of Caucasian/other race/ethnicity (n = 50) (10.2 ± 4.2 vs 16.0 ± 5.6 ng/mL, P < .0001). The 24-hour postoperative 25(OH)D levels were not different from baseline and correlated with a reduced postoperative inotropic requirement (r = -0.316, P = .008). CONCLUSIONS:Vitamin D deficiency is prevalent in neonates with congenital cardiac defects, and lower postoperative 25(OH)D levels are associated with the need for increased inotropic support in neonates undergoing cardiac operations. These findings support that vitamin D deficiency may play a role in myocardial injury and postoperative recovery and warrants further investigation.
RCT Entities:
OBJECTIVES: To determine the incidence of vitamin D deficiency in neonates with congenital heart disease and whether differences exist by race. In addition, we determined the effect of cardiopulmonary bypass on vitamin D levels and explored associations between 25-hydroxyvitamin D [25(OH)D] levels and postoperative outcomes. STUDY DESIGN: We performed a secondary analysis of a prospective randomized controlled trial in 70 neonates undergoing cardiac surgery. The neonates' 25(OH)D levels were measured in the operating room before skin incision (baseline), at the cessation of cardiopulmonary bypass, and at 24 hours postoperatively. Associations between these levels and clinical outcomes were explored. Vitamin D deficiency was defined as a 25(OH)D level <20 ng/mL. RESULTS: Vitamin D deficiency was present in 84% (59/70); concentrations in African Americans (n = 20) were significantly lower than those of Caucasian/other race/ethnicity (n = 50) (10.2 ± 4.2 vs 16.0 ± 5.6 ng/mL, P < .0001). The 24-hour postoperative 25(OH)D levels were not different from baseline and correlated with a reduced postoperative inotropic requirement (r = -0.316, P = .008). CONCLUSIONS: Vitamin D deficiency is prevalent in neonates with congenital cardiac defects, and lower postoperative 25(OH)D levels are associated with the need for increased inotropic support in neonates undergoing cardiac operations. These findings support that vitamin D deficiency may play a role in myocardial injury and postoperative recovery and warrants further investigation.
Authors: James L Vacek; Subba Reddy Vanga; Mathew Good; Sue Min Lai; Dhanunjaya Lakkireddy; Patricia A Howard Journal: Am J Cardiol Date: 2011-11-08 Impact factor: 2.778
Authors: Stuart A Hamilton; Rebecca McNeil; Bruce W Hollis; Deborah J Davis; Joyce Winkler; Carolina Cook; Gloria Warner; Betty Bivens; Patrick McShane; Carol L Wagner Journal: Int J Endocrinol Date: 2010-12-09 Impact factor: 3.257
Authors: James Dayre McNally; Katie O'Hearn; Dean A Fergusson; Jane Lougheed; Dermot R Doherty; Gyaandeo Maharajh; Hope Weiler; Glenville Jones; Ali Khamessan; Stephanie Redpath; Pavel Geier; Lauralyn McIntyre; Margaret L Lawson; Tara Girolamo; Kusum Menon Journal: Pilot Feasibility Stud Date: 2020-10-22
Authors: Dayre McNally; Karin Amrein; Katharine O'Hearn; Dean Fergusson; Pavel Geier; Matt Henderson; Ali Khamessan; Margaret L Lawson; Lauralyn McIntyre; Stephanie Redpath; Hope A Weiler; Kusum Menon Journal: Pilot Feasibility Stud Date: 2017-12-08
Authors: Alparslan Turan; Martin Grady; Jing You; Edward J Mascha; Worasak Keeyapaj; Ryu Komatsu; C Allen Bashour; Daniel I Sessler; Leif Saager; Andrea Kurz Journal: PLoS One Date: 2013-05-28 Impact factor: 3.240