Literature DB >> 23148284

Role of seminal shedding of herpesviruses in HIV Type 1 Transmission.

Sara Gianella1, Sheldon R Morris, Milenka V Vargas, Jason A Young, Bryan Callahan, Douglas D Richman, Susan J Little, Davey M Smith.   

Abstract

To investigate the role of genital shedding of herpesviruses in human immunodeficiency virus type 1 (HIV) transmission, we compared 20 HIV-infected men who did and 26 who did not transmit HIV to their sex partners. As described previously, HIV transmission was associated with the potential source partner having higher levels of HIV RNA in blood and semen, having lower CD4(+) T cell counts, having bacterial coinfections in the genital tract, and not using antiretroviral therapy. This study extended these findings by observing significant associations between HIV transmission and the following characteristics, especially among therapy-naive potential source partners: seminal cytomegalovirus (CMV) shedding, seminal Epstein-Barr virus shedding, and levels of anti CMV immunoglobulin in blood plasma.

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Year:  2012        PMID： 23148284      PMCID： PMC3532824          DOI： 10.1093/infdis/jis683

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  15 in total

1.  Probability of HIV-1 transmission per coital act in monogamous, heterosexual, HIV-1-discordant couples in Rakai, Uganda.

Authors:  R H Gray; M J Wawer; R Brookmeyer; N K Sewankambo; D Serwadda; F Wabwire-Mangen; T Lutalo; X Li; T vanCott; T C Quinn
Journal:  Lancet       Date:  2001-04-14       Impact factor: 79.321

2.  Herpes viruses and HIV-1 drug resistance mutations influence the virologic and immunologic milieu of the male genital tract.

Authors:  Sara Gianella; Sheldon R Morris; Christy Anderson; Celsa A Spina; Milenka V Vargas; Jason A Young; Douglas D Richman; Susan J Little; Davey M Smith
Journal:  AIDS       Date:  2013-01-02       Impact factor: 4.177

3.  Disproportionately high semen shedding of HIV is associated with compartmentalized cytomegalovirus reactivation.

Authors:  Prameet M Sheth; Ali Danesh; Anthony Sheung; Anuradha Rebbapragada; Kamnoosh Shahabi; Colin Kovacs; Roberta Halpenny; David Tilley; Tony Mazzulli; Kelly MacDonald; David Kelvin; Rupert Kaul
Journal:  J Infect Dis       Date:  2005-11-21       Impact factor: 5.226

Review 4.  The effect of genital tract infections on HIV-1 shedding in the genital tract: a systematic review and meta-analysis.

Authors:  Leigh F Johnson; David A Lewis
Journal:  Sex Transm Dis       Date:  2008-11       Impact factor: 2.830

5.  Viral load and heterosexual transmission of human immunodeficiency virus type 1. Rakai Project Study Group.

Authors:  T C Quinn; M J Wawer; N Sewankambo; D Serwadda; C Li; F Wabwire-Mangen; M O Meehan; T Lutalo; R H Gray
Journal:  N Engl J Med       Date:  2000-03-30       Impact factor: 91.245

6.  Cytomegalovirus immunoglobulin G antibody is associated with subclinical carotid artery disease among HIV-infected women.

Authors:  Christina M Parrinello; Elizabeth Sinclair; Alan L Landay; Nell Lurain; A Richey Sharrett; Stephen J Gange; Xiaonan Xue; Peter W Hunt; Steven G Deeks; Howard N Hodis; Robert C Kaplan
Journal:  J Infect Dis       Date:  2012-04-05       Impact factor: 5.226

7.  Herpes simplex virus 2 serostatus and viral loads of HIV-1 in blood and semen as risk factors for HIV transmission among men who have sex with men.

Authors:  David M Butler; Davey M Smith; Edward R Cachay; George K Hightower; Charles Thomas Nugent; Douglas D Richman; Susan J Little
Journal:  AIDS       Date:  2008-08-20       Impact factor: 4.177

8.  Persistence of transmitted drug resistance among subjects with primary human immunodeficiency virus infection.

Authors:  Susan J Little; Simon D W Frost; Joseph K Wong; Davey M Smith; Sergei L Kosakovsky Pond; Caroline C Ignacio; Neil T Parkin; Christos J Petropoulos; Douglas D Richman
Journal:  J Virol       Date:  2008-03-19       Impact factor: 5.103

9.  Associations between virologic and immunologic dynamics in blood and in the male genital tract.

Authors:  Sara Gianella; Matthew C Strain; Steffney E Rought; Milenka V Vargas; Susan J Little; Douglas D Richman; Celsa A Spina; Davey M Smith
Journal:  J Virol       Date:  2011-11-23       Impact factor: 5.103

Review 10.  Herpes simplex virus 2 infection increases HIV acquisition in men and women: systematic review and meta-analysis of longitudinal studies.

Authors:  Esther E Freeman; Helen A Weiss; Judith R Glynn; Pamela L Cross; James A Whitworth; Richard J Hayes
Journal:  AIDS       Date:  2006-01-02       Impact factor: 4.177
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  26 in total

Review 1.  Partners in Crime: The Role of CMV in Immune Dysregulation and Clinical Outcome During HIV Infection.

Authors:  Michael L Freeman; Michael M Lederman; Sara Gianella
Journal:  Curr HIV/AIDS Rep       Date:  2016-02       Impact factor: 5.071

2.  Natural Inhibitor of Human Cytomegalovirus in Human Seminal Plasma.

Authors:  Sina Lippold; Berenike Braun; Franziska Krüger; Mirja Harms; Janis A Müller; Rüdiger Groß; Jan Münch; Jens von Einem
Journal:  J Virol       Date:  2019-03-05       Impact factor: 5.103

3.  Reply to Mounzer and DiNubile.

Authors:  Sheldon R Morris; Davey M Smith; Susan J Little; Sara Gianella
Journal:  J Infect Dis       Date:  2013-05-10       Impact factor: 5.226

Review 4.  Understanding HIV compartments and reservoirs.

Authors:  Valentina Svicher; Francesca Ceccherini-Silberstein; Andrea Antinori; Stefano Aquaro; Carlo Federico Perno
Journal:  Curr HIV/AIDS Rep       Date:  2014-06       Impact factor: 5.071

Review 5.  The Sordid Affair Between Human Herpesvirus and HIV.

Authors:  Sara Gianella; Marta Massanella; Joel O Wertheim; Davey M Smith
Journal:  J Infect Dis       Date:  2015-03-06       Impact factor: 5.226

6.  Vaginal Cytomegalovirus Shedding Before and After Initiation of Antiretroviral Therapy in Rakai, Uganda.

Authors:  Sara Gianella; Andrew D Redd; Mary K Grabowski; Aaron A R Tobian; David Serwadda; Kevin Newell; Eshan U Patel; Sarah Kalibbala; Paschal Ssebbowa; Ronald H Gray; Thomas C Quinn; Steven J Reynolds
Journal:  J Infect Dis       Date:  2015-03-05       Impact factor: 5.226

7.  Penile Immune Activation and Risk of HIV Shedding: A Prospective Cohort Study.

Authors:  Eshan U Patel; Allison R Kirkpatrick; Mary Kate Grabowski; Godfrey Kigozi; Ronald H Gray; Jessica L Prodger; Andrew D Redd; Fred Nalugoda; David Serwadda; Maria J Wawer; Thomas C Quinn; Aaron A R Tobian
Journal:  Clin Infect Dis       Date:  2017-03-15       Impact factor: 9.079

8.  The Association of Human Cytomegalovirus with Biomarkers of Inflammation and Immune Activation in HIV-1-Infected Women.

Authors:  Nell S Lurain; Barbara A Hanson; Anna L Hotton; Kathleen M Weber; Mardge H Cohen; Alan L Landay
Journal:  AIDS Res Hum Retroviruses       Date:  2015-10-22       Impact factor: 2.205

9.  Shedding of HIV and human herpesviruses in the semen of effectively treated HIV-1-infected men who have sex with men.

Authors:  Sara Gianella; Davey M Smith; Milenka V Vargas; Susan J Little; Douglas D Richman; Eric S Daar; Michael P Dube; Fan Zhang; Christina C Ginocchio; Richard H Haubrich; Sheldon R Morris
Journal:  Clin Infect Dis       Date:  2013-04-17       Impact factor: 9.079

10.  Virologic correlates of anti-CMV IgG levels in HIV-1-infected men.

Authors:  Sara Gianella; Sheldon R Morris; Erick Tatro; Milenka V Vargas; Richard H Haubrich; Eric S Daar; Michael P Dube; Douglas D Richman; Susan J Little; Davey M Smith
Journal:  J Infect Dis       Date:  2013-08-20       Impact factor: 5.226
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