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Literature DB >> 23147739

Inhibition of Streptococcus pneumoniae penicillin-binding protein 2x and Actinomadura R39 DD-peptidase activities by ceftaroline.

Astrid Zervosen¹, André Zapun, Jean-Marie Frère.

Abstract

Although the rate of acylation of a penicillin-resistant form of Streptococcus pneumoniae penicillin-binding protein 2x (PBP2x) by ceftaroline is 80-fold lower than that of its penicillin-sensitive counterpart, it remains sufficiently high (k(2)/K = 12,600 M(-1) s(-1)) to explain the sensitivity of the penicillin-resistant strain to this new cephalosporin. Surprisingly, the Actinomadura R39 DD-peptidase is not very sensitive to ceftaroline.

Entities: Chemical Disease Species

Mesh：

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Year: 2012 PMID： 23147739 PMCID： PMC3535952 DOI： 10.1128/AAC.01593-12

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

17 in total

1. Genetics of resistance to third-generation cephalosporins in clinical isolates of Streptococcus pneumoniae.

Authors: R Muñoz; C G Dowson; M Daniels; T J Coffey; C Martin; R Hakenbeck; B G Spratt
Journal: Mol Microbiol Date: 1992-09 Impact factor: 3.501

2. Identical penicillin-binding domains in penicillin-binding proteins of Streptococcus pneumoniae clinical isolates with different levels of beta-lactam resistance.

Authors: Laurent Chesnel; Raphaël Carapito; Jacques Croizé; Otto Dideberg; Thierry Vernet; André Zapun
Journal: Antimicrob Agents Chemother Date: 2005-07 Impact factor: 5.191

3. Automated analysis of enzyme inactivation phenomena. Application to beta-lactamases and DD-peptidases.

Authors: F De Meester; B Joris; G Reckinger; C Bellefroid-Bourguignon; J M Frère; S G Waley
Journal: Biochem Pharmacol Date: 1987-07-15 Impact factor: 5.858

4. Penicillin binding protein 2x as a major contributor to intrinsic beta-lactam resistance of Streptococcus pneumoniae.

Authors: M Jamin; R Hakenbeck; J M Frere
Journal: FEBS Lett Date: 1993-09-27 Impact factor: 4.124

5. Serine-type D-Ala-D-Ala peptidases and penicillin-binding proteins.

Authors: B Granier; M Jamin; M Adam; M Galleni; B Lakaye; W Zorzi; J Grandchamps; J M Wilkin; C Fraipont; B Joris
Journal: Methods Enzymol Date: 1994 Impact factor: 1.600

6. Mosaic genes and mosaic chromosomes: intra- and interspecies genomic variation of Streptococcus pneumoniae.

Authors: R Hakenbeck; N Balmelle; B Weber; C Gardès; W Keck; A de Saizieu
Journal: Infect Immun Date: 2001-04 Impact factor: 3.441

7. Interspecies recombinational events during the evolution of altered PBP 2x genes in penicillin-resistant clinical isolates of Streptococcus pneumoniae.

Authors: G Laible; B G Spratt; R Hakenbeck
Journal: Mol Microbiol Date: 1991-08 Impact factor: 3.501

Inhibition of Streptococcus pneumoniae penicillin-binding protein 2x and Actinomadura R39 DD-peptidase activities by ceftaroline.

1. Genetics of resistance to third-generation cephalosporins in clinical isolates of Streptococcus pneumoniae.

2. Identical penicillin-binding domains in penicillin-binding proteins of Streptococcus pneumoniae clinical isolates with different levels of beta-lactam resistance.

3. Automated analysis of enzyme inactivation phenomena. Application to beta-lactamases and DD-peptidases.

4. Penicillin binding protein 2x as a major contributor to intrinsic beta-lactam resistance of Streptococcus pneumoniae.

5. Serine-type D-Ala-D-Ala peptidases and penicillin-binding proteins.

6. Mosaic genes and mosaic chromosomes: intra- and interspecies genomic variation of Streptococcus pneumoniae.

7. Interspecies recombinational events during the evolution of altered PBP 2x genes in penicillin-resistant clinical isolates of Streptococcus pneumoniae.

8. Penicillin-binding protein 2x of Streptococcus pneumoniae: enzymic activities and interactions with beta-lactams.

9. Identification of a structural determinant for resistance to beta-lactam antibiotics in Gram-positive bacteria.

10. Synthesis and evaluation of boronic acids as inhibitors of Penicillin Binding Proteins of classes A, B and C.

1. Activity of ceftaroline against Enterococcus faecium PBP5.

2. Discovery of Pyrrolidine-2,3-diones as Novel Inhibitors of P. aeruginosa PBP3.

Review 3. Glycosyltransferases and Transpeptidases/Penicillin-Binding Proteins: Valuable Targets for New Antibacterials.