OBJECTIVE: To evaluate the association between exposure to chlorinated solvents and cancer. METHODS: We conducted a case-control study of occupational exposures and cancer in Montreal, Quebec, Canada, including 3730 cancer cases and 533 population controls. Occupational exposures were derived using a combination of subject-reported job history and expert assessment. We examined the associations between two chemical families and six chlorinated solvents with 11 sites of cancer. RESULTS: The majority of the associations examined were null, although many were based on small numbers. We found two significantly elevated odds ratios (ORs), one between perchloroethylene and prostate cancer (OR = 4.3; 95% CI: 1.4 to 13) and another between trichloroethylene and melanoma (OR = 3.2; 95% CI: 1.0 to 9.9). CONCLUSIONS: There was little evidence of associations between chlorinated solvents and cancer. Limited power precludes strong inferences about absence of risk. We raise hypotheses about two possible associations: perchloroethylene with prostate cancer and trichloroethylene with melanoma.
OBJECTIVE: To evaluate the association between exposure to chlorinated solvents and cancer. METHODS: We conducted a case-control study of occupational exposures and cancer in Montreal, Quebec, Canada, including 3730 cancer cases and 533 population controls. Occupational exposures were derived using a combination of subject-reported job history and expert assessment. We examined the associations between two chemical families and six chlorinated solvents with 11 sites of cancer. RESULTS: The majority of the associations examined were null, although many were based on small numbers. We found two significantly elevated odds ratios (ORs), one between perchloroethylene and prostate cancer (OR = 4.3; 95% CI: 1.4 to 13) and another between trichloroethylene and melanoma (OR = 3.2; 95% CI: 1.0 to 9.9). CONCLUSIONS: There was little evidence of associations between chlorinated solvents and cancer. Limited power precludes strong inferences about absence of risk. We raise hypotheses about two possible associations: perchloroethylene with prostate cancer and trichloroethylene with melanoma.
Authors: Mark P Purdue; Patricia A Stewart; Melissa C Friesen; Joanne S Colt; Sarah J Locke; Misty J Hein; Martha A Waters; Barry I Graubard; Faith Davis; Julie Ruterbusch; Kendra Schwartz; Wong-Ho Chow; Nathaniel Rothman; Jonathan N Hofmann Journal: Occup Environ Med Date: 2016-11-01 Impact factor: 4.402
Authors: Joseph A Cichocki; Kathryn Z Guyton; Neela Guha; Weihsueh A Chiu; Ivan Rusyn; Lawrence H Lash Journal: J Pharmacol Exp Ther Date: 2016-08-10 Impact factor: 4.030
Authors: Ivan Rusyn; Weihsueh A Chiu; Lawrence H Lash; Hans Kromhout; Johnni Hansen; Kathryn Z Guyton Journal: Pharmacol Ther Date: 2013-08-23 Impact factor: 12.310
Authors: Jelle Vlaanderen; Kurt Straif; Avima Ruder; Aaron Blair; Johnni Hansen; Elsebeth Lynge; Barbara Charbotel; Dana Loomis; Timo Kauppinen; Pentti Kyyronen; Eero Pukkala; Elisabete Weiderpass; Neela Guha Journal: Environ Health Perspect Date: 2014-03-21 Impact factor: 9.031
Authors: Kathryn Z Guyton; Karen A Hogan; Cheryl Siegel Scott; Glinda S Cooper; Ambuja S Bale; Leonid Kopylev; Stanley Barone; Susan L Makris; Barbara Glenn; Ravi P Subramaniam; Maureen R Gwinn; Rebecca C Dzubow; Weihsueh A Chiu Journal: Environ Health Perspect Date: 2014-02-14 Impact factor: 9.031