Literature DB >> 23147549

Expression of costimulatory molecule B7-H4 in human malignant tumors.

Xiao Zheng1, Xiao-Dong Li, Chang-Ping Wu, Bin-Feng Lu, Jing-Ting Jiang.   

Abstract

Costimulatory molecule B7-H4, a member of the B7 family, negatively regulates the immune response of T cells through inhibiting their proliferation, cytokine production and cell cycle. The overexpression of B7-H4 plays an important role in initiation, progression and regression of tumors by promoting malignant transformation of epithelial cells and protecting epithelial cells from anoikis. B7-H4 expression in malignant tumors is useful for clinical diagnosis, and may provide a novel molecular target for cancer treatment.

Entities:  

Mesh：

Substances：

Year:  2012        PMID： 23147549     DOI： 10.1159/000343638

Source DB:  PubMed          Journal:  Onkologie        ISSN： 0378-584X


  5 in total

1.  B7-H4 downregulation induces mitochondrial dysfunction and enhances doxorubicin sensitivity via the cAMP/CREB/PGC1-α signaling pathway in HeLa cells.

Authors:  Hyoung Kyu Kim; In-Sung Song; Sun Young Lee; Seung Hun Jeong; Sung Ryul Lee; Hye Jin Heo; Vu Thi Thu; Nari Kim; Kyung Soo Ko; Byoung Doo Rhee; Dae Hun Jeong; Young Nam Kim; Jin Han
Journal:  Pflugers Arch       Date:  2014-12       Impact factor: 3.657

2.  Increased B7H4 tissue expression correlates with high CA19.9 serum levels and a worse prognosis of pancreatic adenocarcinoma.

Authors:  Anastasia Tsiaousidou; A K Tsaroucha; M Lambropoulou; M Pitiakoudis; A Polychronidis; E Chatzitheoklitos; K Romanidis; C Simopoulos
Journal:  Clin Exp Med       Date:  2015-04-30       Impact factor: 3.984

3.  Expression of costimulatory molecules B7-H1, B7-H4 and Foxp3+ Tregs in gastric cancer and its clinical significance.

Authors:  Yiting Geng; Hui Wang; Changqing Lu; Qing Li; Bin Xu; Jingting Jiang; Changping Wu
Journal:  Int J Clin Oncol       Date:  2014-05-09       Impact factor: 3.402

4.  Expression of selected regulatory molecules on the CD83+ monocyte-derived dendritic cells generated from patients with laryngeal cancer and their clinical significance.

Authors:  Janusz Klatka; Ewelina Grywalska; Maria Klatka; Magdalena Wasiak; Adrian Andrzejczak; Jacek Rolinski
Journal:  Eur Arch Otorhinolaryngol       Date:  2013-04-30       Impact factor: 2.503

5.  Prognostic significance of B7-H4 expression in matched primary pancreatic cancer and liver metastases.

Authors:  Yun Qian; Yiwen Sang; Frederick X C Wang; Bo Hong; Qi Wang; Xinhui Zhou; Tianhao Weng; Zhigang Wu; Min Zheng; Hong Zhang; Hangping Yao
Journal:  Oncotarget       Date:  2016-11-01
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.