Literature DB >> 23147065

Structural basis of single molecular heparin-FX06 interaction revealed by SPM measurements and molecular simulations.

Cunlan Guo1, Bin Wang, Lianchun Wang, Bingqian Xu.   

Abstract

Heparin, a functionalized polysaccharide, is observed under a scanning tunneling microscope, which shows atomic scale conformational details. The peptide FX06 is found to bind to five consecutive sugar units of heparin and this interaction is directly revealed by atomic force microscopy and dynamic force spectroscopy measurements. The determined free energy change agrees well with the dynamic calculation result.

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Year:  2012        PMID： 23147065      PMCID： PMC3508726          DOI： 10.1039/c2cc36546d

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  22 in total

Review 1.  Single molecule force spectroscopy in biology using the atomic force microscope.

Authors:  J Zlatanova; S M Lindsay; S H Leuba
Journal:  Prog Biophys Mol Biol       Date:  2000       Impact factor: 3.667

Review 2.  Order out of complexity--protein structures that interact with heparin.

Authors:  B Mulloy; R J Linhardt
Journal:  Curr Opin Struct Biol       Date:  2001-10       Impact factor: 6.809

Review 3.  Probing the relation between force--lifetime--and chemistry in single molecular bonds.

Authors:  E Evans
Journal:  Annu Rev Biophys Biomol Struct       Date:  2001

Review 4.  Order out of chaos: assembly of ligand binding sites in heparan sulfate.

Authors:  Jeffrey D Esko; Scott B Selleck
Journal:  Annu Rev Biochem       Date:  2001-11-09       Impact factor: 23.643

5.  Single-molecule recognition imaging microscopy.

Authors:  C Stroh; H Wang; R Bash; B Ashcroft; J Nelson; H Gruber; D Lohr; S M Lindsay; P Hinterdorfer
Journal:  Proc Natl Acad Sci U S A       Date:  2004-08-16       Impact factor: 11.205

Review 6.  The chemical neurobiology of carbohydrates.

Authors:  Heather E Murrey; Linda C Hsieh-Wilson
Journal:  Chem Rev       Date:  2008-05-02       Impact factor: 60.622

7.  The R.E.D. tools: advances in RESP and ESP charge derivation and force field library building.

Authors:  François-Yves Dupradeau; Adrien Pigache; Thomas Zaffran; Corentin Savineau; Rodolphe Lelong; Nicolas Grivel; Dimitri Lelong; Wilfried Rosanski; Piotr Cieplak
Journal:  Phys Chem Chem Phys       Date:  2010-06-23       Impact factor: 3.676

8.  Heparin-binding domain of fibrin mediates its binding to endothelial cells.

Authors:  T M Odrljin; C W Francis; L A Sporn; L A Bunce; V J Marder; P J Simpson-Haidaris
Journal:  Arterioscler Thromb Vasc Biol       Date:  1996-12       Impact factor: 8.311

9.  Effect of intravenous FX06 as an adjunct to primary percutaneous coronary intervention for acute ST-segment elevation myocardial infarction results of the F.I.R.E. (Efficacy of FX06 in the Prevention of Myocardial Reperfusion Injury) trial.

Authors:  Dan Atar; Peter Petzelbauer; Jürg Schwitter; Kurt Huber; Benno Rensing; Jaroslaw D Kasprzak; Christian Butter; Lars Grip; Peter R Hansen; Tim Süselbeck; Peter M Clemmensen; Marcos Marin-Galiano; Bernard Geudelin; Peter T Buser
Journal:  J Am Coll Cardiol       Date:  2009-02-24       Impact factor: 24.094

10.  Semi-rigid solution structures of heparin by constrained X-ray scattering modelling: new insight into heparin-protein complexes.

Authors:  Sanaullah Khan; Jayesh Gor; Barbara Mulloy; Stephen J Perkins
Journal:  J Mol Biol       Date:  2009-11-03       Impact factor: 5.469
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  3 in total

1.  Investigation of the heparin-thrombin interaction by dynamic force spectroscopy.

Authors:  Congzhou Wang; Yingzi Jin; Umesh R Desai; Vamsi K Yadavalli
Journal:  Biochim Biophys Acta       Date:  2015-01-31

2.  High-resolution probing heparan sulfate-antithrombin interaction on a single endothelial cell surface: single-molecule AFM studies.

Authors:  Cunlan Guo; Xian Fan; Hong Qiu; Wenyuan Xiao; Lianchun Wang; Bingqian Xu
Journal:  Phys Chem Chem Phys       Date:  2015-05-28       Impact factor: 3.676

3.  A "turn on" fluorescent probe for heparin and its oversulfated chondroitin sulfate contaminant.

Authors:  Yubin Ding; Leilei Shi; Hui Wei
Journal:  Chem Sci       Date:  2015-07-23       Impact factor: 9.825
  3 in total

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