Literature DB >> 23146899

Characterizing the assembly behaviors of human amylin: a perspective derived from C-terminal variants.

Mei-Sha Chen1, De-Sheng Zhao, Ye-Ping Yu, Wei-Wei Li, Yong-Xiang Chen, Yu-Fen Zhao, Yan-Mei Li.   

Abstract

The differences in the C-terminal domains of human amylin peptide variants initiate different aggregation processes and differences in the composition of the aggregates by affecting the hydrophobic cores, conformations, and intra-sheet interactions of the peptides, which have distinct effects on the cytotoxicity of the peptides.

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Year:  2012        PMID： 23146899     DOI： 10.1039/c2cc33432a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  8 in total

1.  Matrix Metalloproteinase-9 Protects Islets from Amyloid-induced Toxicity.

Authors:  Daniel T Meier; Ling-Hsien Tu; Sakeneh Zraika; Meghan F Hogan; Andrew T Templin; Rebecca L Hull; Daniel P Raleigh; Steven E Kahn
Journal:  J Biol Chem       Date:  2015-10-19       Impact factor: 5.157

2.  Analysis of Baboon IAPP Provides Insight into Amyloidogenicity and Cytotoxicity of Human IAPP.

Authors:  Zachary Ridgway; Kyung-Hoon Lee; Alexander Zhyvoloup; Amy Wong; Charles Eldrid; Eleni Hannaberry; Konstantinos Thalassinos; Andisheh Abedini; Daniel P Raleigh
Journal:  Biophys J       Date:  2020-01-03       Impact factor: 4.033

3.  Tuning the rate of aggregation of hIAPP into amyloid using small-molecule modulators of assembly.

Authors:  Yong Xu; Roberto Maya-Martinez; Nicolas Guthertz; George R Heath; Iain W Manfield; Alexander L Breeze; Frank Sobott; Richard Foster; Sheena E Radford
Journal:  Nat Commun       Date:  2022-02-24       Impact factor: 17.694

4.  Analysis of the ability of pramlintide to inhibit amyloid formation by human islet amyloid polypeptide reveals a balance between optimal recognition and reduced amyloidogenicity.

Authors:  Hui Wang; Zachary Ridgway; Ping Cao; Bela Ruzsicska; Daniel P Raleigh
Journal:  Biochemistry       Date:  2015-10-30       Impact factor: 3.162

5.  Mutational analysis of preamyloid intermediates: the role of his-tyr interactions in islet amyloid formation.

Authors:  Ling-Hsien Tu; Arnaldo L Serrano; Martin T Zanni; Daniel P Raleigh
Journal:  Biophys J       Date:  2014-04-01       Impact factor: 4.033

6.  Time-resolved studies define the nature of toxic IAPP intermediates, providing insight for anti-amyloidosis therapeutics.

Authors:  Andisheh Abedini; Annette Plesner; Ping Cao; Zachary Ridgway; Jinghua Zhang; Ling-Hsien Tu; Chris T Middleton; Brian Chao; Daniel J Sartori; Fanling Meng; Hui Wang; Amy G Wong; Martin T Zanni; C Bruce Verchere; Daniel P Raleigh; Ann Marie Schmidt
Journal:  Elife       Date:  2016-05-23       Impact factor: 8.140

7.  Effect of Post-Translational Amidation on Islet Amyloid Polypeptide Conformational Ensemble: Implications for Its Aggregation Early Steps.

Authors:  Linh Tran; Tâp Ha-Duong
Journal:  Int J Mol Sci       Date:  2016-11-14       Impact factor: 5.923

8.  The triphenylmethane dye brilliant blue G is only moderately effective at inhibiting amyloid formation by human amylin or at disaggregating amylin amyloid fibrils, but interferes with amyloid assays; Implications for inhibitor design.

Authors:  Rehana Akter; Alexander Zhyvoloup; Bingqian Zheng; Surita R Bhatia; Daniel P Raleigh
Journal:  PLoS One       Date:  2019-08-12       Impact factor: 3.240
  8 in total

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