SETTING: A tertiary care centre in Mumbai, India. OBJECTIVE: To estimate the extent of association between inhA mutant isoniazid (INH) resistant strains and ethionamide (ETH) resistance. DESIGN: A total of 140 clinical isolates processed for INH and ETH phenotypic drug susceptibility testing, and molecularly processed with the line-probe assay (LPA) Genotype® MTBDRplus, were considered. RESULTS: Among the 112 phenotypically determined INH-resistant strains, 69 (61.6%) strains were ETH-resistant. An inhA promoter mutation was identified in 24 (21.4%) INH-resistant isolates, 21 (87.5%) of which were ETH-resistant (P < 0.0001). CONCLUSION: An inhA promoter mutation could be considered as a marker for the determination of ETH resistance in India, where the use of LPA is being expanded.
SETTING: A tertiary care centre in Mumbai, India. OBJECTIVE: To estimate the extent of association between inhA mutant isoniazid (INH) resistant strains and ethionamide (ETH) resistance. DESIGN: A total of 140 clinical isolates processed for INH and ETH phenotypic drug susceptibility testing, and molecularly processed with the line-probe assay (LPA) Genotype® MTBDRplus, were considered. RESULTS: Among the 112 phenotypically determined INH-resistant strains, 69 (61.6%) strains were ETH-resistant. An inhA promoter mutation was identified in 24 (21.4%) INH-resistant isolates, 21 (87.5%) of which were ETH-resistant (P < 0.0001). CONCLUSION: An inhA promoter mutation could be considered as a marker for the determination of ETH resistance in India, where the use of LPA is being expanded.
Authors: V R Bollela; E I Namburete; C S Feliciano; D Macheque; L H Harrison; J A Caminero Journal: Int J Tuberc Lung Dis Date: 2016-08 Impact factor: 2.373
Authors: Rajagopalan Lakshmi; Ranjani Ramachandran; D Ravi Kumar; A Syam Sundar; G Radhika; Fathima Rahman; N Selvakumar; Vanaja Kumar Journal: Indian J Med Res Date: 2015-11 Impact factor: 2.375
Authors: Karen R Jacobson; Marinus Barnard; Mary B Kleinman; Elizabeth M Streicher; Elizabeth J Ragan; Laura F White; Ofer Shapira; Tania Dolby; John Simpson; Lesley Scott; Wendy Stevens; Paul D van Helden; Annelies Van Rie; Robin M Warren Journal: Clin Infect Dis Date: 2017-06-01 Impact factor: 9.079