INTRODUCTION: Regulatory T cells (Tregs) have gained an important role in mechanisms of tolerance and protection against the transplant rejection. However, only limited retrospective data have shown a relationship between peripheral blood Tregs and better long-term graft survival. The purpose of the present study was to investigate prospectively circulating Treg levels and their association with long-term graft survival. METHODS: Ninety kidney transplant recipients underwent measurement of Treg levels in peripheral blood before as well as at 6 months and 1 year posttransplantation. Receiver operating characteristic curves were applied to test the sensitivity and specificity of Treg levels to predict prognosis. RESULTS: Treg levels before transplantation correlated with those at 6 months and 12 months posttransplantation (P < .001 and P = .002, respectively). Patients who maintained high Treg levels (above 70th percentile) at both 6 and 12 months displayed better long-term graft survival at 4 and 5 years follow-up (P = .04 and P = .043 respectively). There was no effect on patient survival. CONCLUSION: Detection of high levels of peripheral blood Tregs was associated with better graft survival possibly using as a potential marker of prognosis.
INTRODUCTION: Regulatory T cells (Tregs) have gained an important role in mechanisms of tolerance and protection against the transplant rejection. However, only limited retrospective data have shown a relationship between peripheral blood Tregs and better long-term graft survival. The purpose of the present study was to investigate prospectively circulating Treg levels and their association with long-term graft survival. METHODS: Ninety kidney transplant recipients underwent measurement of Treg levels in peripheral blood before as well as at 6 months and 1 year posttransplantation. Receiver operating characteristic curves were applied to test the sensitivity and specificity of Treg levels to predict prognosis. RESULTS: Treg levels before transplantation correlated with those at 6 months and 12 months posttransplantation (P < .001 and P = .002, respectively). Patients who maintained high Treg levels (above 70th percentile) at both 6 and 12 months displayed better long-term graft survival at 4 and 5 years follow-up (P = .04 and P = .043 respectively). There was no effect on patient survival. CONCLUSION: Detection of high levels of peripheral blood Tregs was associated with better graft survival possibly using as a potential marker of prognosis.
Authors: David San Segundo; Luis H Galván-Espinoza; Emilio Rodrigo; Juan Irure; Juan C Ruiz; Gema Fernández-Fresnedo; Laura Riesco; Jairo Bada; Lara Belmar; Marcos Lopez-Hoyos Journal: Transplant Direct Date: 2019-02-08
Authors: Anna Gronert Álvarez; Paraskevi Fytili; Pothakamuri V Suneetha; Anke R M Kraft; Christin Brauner; Jerome Schlue; Till Krech; Frank Lehner; Christoph Meyer-Heithuis; Elmar Jaeckel; Juergen Klempnauer; Michael P Manns; Markus Cornberg; Heiner Wedemeyer Journal: Liver Transpl Date: 2015-01-20 Impact factor: 5.799
Authors: Mostafa G Aly; Karina Trojan; Rolf Weimer; Christian Morath; Gerhard Opelz; Mohammed A Tohamy; Volker Daniel Journal: BMC Pharmacol Toxicol Date: 2016-06-14 Impact factor: 2.483