Literature DB >> 23143930

IsoDGR-tagged albumin: a new αvβ3 selective carrier for nanodrug delivery to tumors.

Flavio Curnis1, Angelina Sacchi, Renato Longhi, Barbara Colombo, Anna Gasparri, Angelo Corti.   

Abstract

A new cyclic peptide containing the isoDGR motif that, after coupling to albumin, selectively binds αvβ3, an integrin overexpressed in the tumor vasculature. IsoDGR-tagged albumin binds tumor vessels and can be exploited as a carrier for the preparation of tumor vasculature-selective nanomedicines, such as gold nanoparticles (Au) carrying tumor necrosis factor α (TNF), a potent vascular damaging agent.
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Year:  2012        PMID： 23143930     DOI： 10.1002/smll.201202310

Source DB:  PubMed          Journal:  Small        ISSN： 1613-6810            Impact factor:   13.281


  10 in total

Review 1.  Elucidating Solution Structures of Cyclic Peptides Using Molecular Dynamics Simulations.

Authors:  Jovan Damjanovic; Jiayuan Miao; He Huang; Yu-Shan Lin
Journal:  Chem Rev       Date:  2021-01-11       Impact factor: 60.622

Review 2.  Peptide-mediated targeting of cytokines to tumor vasculature: the NGR-hTNF example.

Authors:  Angelo Corti; Flavio Curnis; Gilda Rossoni; Fabrizio Marcucci; Vanesa Gregorc
Journal:  BioDrugs       Date:  2013-12       Impact factor: 5.807

3.  GX1-conjugated poly(lactic acid) nanoparticles encapsulating Endostar for improved in vivo anticolorectal cancer treatment.

Authors:  Yang Du; Qian Zhang; Lijia Jing; Xiaolong Liang; Chongwei Chi; Yaqian Li; Xin Yang; Zhifei Dai; Jie Tian
Journal:  Int J Nanomedicine       Date:  2015-05-28

4.  Tumor Targeting with an isoDGR-Drug Conjugate.

Authors:  Simone Zanella; Simona Angerani; Arianna Pina; Paula López Rivas; Clelia Giannini; Silvia Panzeri; Daniela Arosio; Michele Caruso; Fabio Gasparri; Ivan Fraietta; Clara Albanese; Aurelio Marsiglio; Luca Pignataro; Laura Belvisi; Umberto Piarulli; Cesare Gennari
Journal:  Chemistry       Date:  2017-05-26       Impact factor: 5.236

5.  Succinimide Formation from an NGR-Containing Cyclic Peptide: Computational Evidence for Catalytic Roles of Phosphate Buffer and the Arginine Side Chain.

Authors:  Ryota Kirikoshi; Noriyoshi Manabe; Ohgi Takahashi
Journal:  Int J Mol Sci       Date:  2017-02-16       Impact factor: 5.923

6.  Enhancement of doxorubicin anti-cancer activity by vascular targeting using IsoDGR/cytokine-coated nanogold.

Authors:  Angelo Corti; Angelina Sacchi; Anna Maria Gasparri; Matteo Monieri; Giulia Anderluzzi; Barbara Colombo; Alessandro Gori; Anna Mondino; Flavio Curnis
Journal:  J Nanobiotechnology       Date:  2021-05-05       Impact factor: 10.435

7.  A Novel RGD-4C-Saporin Conjugate Inhibits Tumor Growth in Mouse Models of Bladder Cancer.

Authors:  Stefania Zuppone; Chiara Assalini; Claudia Minici; Oronza A Botrugno; Flavio Curnis; Massimo Degano; Angelo Corti; Francesco Montorsi; Andrea Salonia; Riccardo Vago
Journal:  Front Oncol       Date:  2022-04-11       Impact factor: 5.738

Review 8.  Strategies for Preparing Albumin-based Nanoparticles for Multifunctional Bioimaging and Drug Delivery.

Authors:  Fei-Fei An; Xiao-Hong Zhang
Journal:  Theranostics       Date:  2017-08-23       Impact factor: 11.556

9.  Glycine N-methylation in NGR-Tagged Nanocarriers Prevents Isoaspartate formation and Integrin Binding without Impairing CD13 Recognition and Tumor Homing.

Authors:  Angelo Corti; Anna Maria Gasparri; Michela Ghitti; Angelina Sacchi; Francesco Sudati; Martina Fiocchi; Valentina Buttiglione; Laura Perani; Alessandro Gori; Silvia Valtorta; Rosa Maria Moresco; Fabio Pastorino; Mirco Ponzoni; Giovanna Musco; Flavio Curnis
Journal:  Adv Funct Mater       Date:  2017-09-26       Impact factor: 18.808

10.  NGR-tagged nano-gold: A new CD13-selective carrier for cytokine delivery to tumors.

Authors:  Flavio Curnis; Martina Fiocchi; Angelina Sacchi; Alessandro Gori; Anna Gasparri; Angelo Corti
Journal:  Nano Res       Date:  2016-03-04       Impact factor: 8.897
  10 in total

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