BACKGROUND: Body mass index (BMI) and waist circumference (WC) may be associated with lung function in children, as observed in adults. METHODS: Height, weight, waist circumference, and lung function (FVC and FEV1 ) were measured during a medical examination in 1,058 eight-year-old children participating in the Prevention and Incidence of Asthma and Mite Allergy (PIAMA) birth cohort study. RESULTS: After adjusting for height, age and other potential confounders large WC or high BMI (>90th percentile) were not associated with forced expiratory volume in 1 sec (FEV1) or forced vital capacity (FVC). In girls only, large WC was, independently of BMI, associated with 3.5% (95% confidence interval (CI): -6.4, -0.6) lower FEV1 /FVC ratio in the model including WC and BMI. Girls with low BMI (<10th percentile) had 4.6% lower FEV1 (95% CI: -8.4, -0.6) and 5.1% lower FVC (95% CI: -8.8, -1.2) than girls with normal BMI. In boys, we did not observe associations between low or high BMI and lung function independent of WC, or between small or large WC and lung function after adjustment for BMI. CONCLUSION: At 8 years of age, a high BMI or large WC are not yet associated with FEV1 and FVC, indicating that this association may change over the course of life from childhood to adulthood.
BACKGROUND: Body mass index (BMI) and waist circumference (WC) may be associated with lung function in children, as observed in adults. METHODS: Height, weight, waist circumference, and lung function (FVC and FEV1 ) were measured during a medical examination in 1,058 eight-year-old children participating in the Prevention and Incidence of Asthma and Mite Allergy (PIAMA) birth cohort study. RESULTS: After adjusting for height, age and other potential confounders large WC or high BMI (>90th percentile) were not associated with forced expiratory volume in 1 sec (FEV1) or forced vital capacity (FVC). In girls only, large WC was, independently of BMI, associated with 3.5% (95% confidence interval (CI): -6.4, -0.6) lower FEV1 /FVC ratio in the model including WC and BMI. Girls with low BMI (<10th percentile) had 4.6% lower FEV1 (95% CI: -8.4, -0.6) and 5.1% lower FVC (95% CI: -8.8, -1.2) than girls with normal BMI. In boys, we did not observe associations between low or high BMI and lung function independent of WC, or between small or large WC and lung function after adjustment for BMI. CONCLUSION: At 8 years of age, a high BMI or large WC are not yet associated with FEV1 and FVC, indicating that this association may change over the course of life from childhood to adulthood.
Authors: Carlos A Camargo; G R Scott Budinger; Gabriel J Escobar; Nadia N Hansel; Corrine K Hanson; Gary B Huffnagle; A Sonia Buist Journal: Ann Am Thorac Soc Date: 2014-04
Authors: Marga B Bekkers; Alet H Wijga; Ulrike Gehring; Gerard H Koppelman; Johan C de Jongste; Henriette A Smit; Bert Brunekreef Journal: BMC Pulm Med Date: 2015-04-22 Impact factor: 3.317
Authors: Magnus Svartengren; Gui-Hong Cai; Andrei Malinovschi; Jenny Theorell-Haglöw; Christer Janson; Sölve Elmståhl; Lars Lind; Erik Lampa; Eva Lindberg Journal: ERJ Open Res Date: 2020-11-02
Authors: R N Khramova; E V Tush; A A Khramov; D Yu Ovsyannikov; K S Popov; I V Dolbin; O V Khaletskaya; A B Stroganov; N I Kubysheva; T I Eliseeva Journal: Sovrem Tekhnologii Med Date: 2020-06-28
Authors: Anna Bergström; Erik Melén; Sandra Ekström; Jenny Hallberg; Inger Kull; Jennifer L P Protudjer; Per Thunqvist; Matteo Bottai; Per Magnus Gustafsson Journal: Thorax Date: 2018-01-29 Impact factor: 9.139
Authors: Abdelilah Benslimane; Vanessa Garcia-Larsen; Khaoula El Kinany; Amina Alaoui Chrifi; Zineb Hatime; Mohamed Chakib Benjelloun; Mohammed El Biaze; Chakib Nejjari; Karima El Rhazi Journal: SAGE Open Med Date: 2021-07-17