Literature DB >> 23142671

Synthesis and biological evaluation of some hydrazone derivatives as new anticandidal and anticancer agents.

Mehlika Dilek Altıntop1, Ahmet Özdemir, Gülhan Turan-Zitouni, Sinem Ilgın, Özlem Atlı, Gökalp İşcan, Zafer Asım Kaplancıklı.   

Abstract

New hydrazone derivatives were synthesized via the nucleophilic addition-elimination reaction of 2-[(1-methyl-1H-tetrazol-5-yl)thio)]acetohydrazide with aromatic aldehydes/ketones. The compounds were tested in vitro against various Candida species and compared with ketoconazole. Genotoxicity of the most effective anticandidal compounds was evaluated by umuC and Ames assays. All compounds were also investigated for their cytotoxic effects on NIH3T3 and A549 cell lines. Compound 8 was the most effective antifungal derivative against C. albicans (ATCC-90028) with a MIC value of 0.05 mg/mL. Compound 5 can be identified as the most promising anticancer agent against A549 cancer cell lines due to its inhibitory effect on A549 cell lines and low toxicity to NIH3T3 cells.
Copyright © 2012 Elsevier Masson SAS. All rights reserved.

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Year:  2012        PMID： 23142671     DOI： 10.1016/j.ejmech.2012.10.011

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  7 in total

1.  Design, Synthesis and Evaluation of the Biological Activities of Some New Carbohydrazide and Urea Derivatives.

Authors:  Fatih Tok; Recep Ilhan; Selin Günal; Petek Ballar-Kirmizibayrak; Bedia Koçyiğit-Kaymakçioğlu
Journal:  Turk J Pharm Sci       Date:  2018-11-20

2.  Identification of a New Class of Antifungals Targeting the Synthesis of Fungal Sphingolipids.

Authors:  Visesato Mor; Antonella Rella; Amir M Farnoud; Ashutosh Singh; Mansa Munshi; Arielle Bryan; Shamoon Naseem; James B Konopka; Iwao Ojima; Erika Bullesbach; Alan Ashbaugh; Michael J Linke; Melanie Cushion; Margaret Collins; Hari Krishna Ananthula; Larry Sallans; Pankaj B Desai; Nathan P Wiederhold; Annette W Fothergill; William R Kirkpatrick; Thomas Patterson; Lai Hong Wong; Sunita Sinha; Guri Giaever; Corey Nislow; Patrick Flaherty; Xuewen Pan; Gabriele Vargas Cesar; Patricia de Melo Tavares; Susana Frases; Kildare Miranda; Marcio L Rodrigues; Chiara Luberto; Leonardo Nimrichter; Maurizio Del Poeta
Journal:  mBio       Date:  2015-06-23       Impact factor: 7.867

3.  Novel amphiphilic pyridinium ionic liquids-supported Schiff bases: ultrasound assisted synthesis, molecular docking and anticancer evaluation.

Authors:  Fawzia Faleh Al-Blewi; Nadjet Rezki; Salsabeel Abdullah Al-Sodies; Sanaa K Bardaweel; Dima A Sabbah; Mouslim Messali; Mohamed Reda Aouad
Journal:  Chem Cent J       Date:  2018-11-22       Impact factor: 4.215

4.  Novel allyl-hydrazones including 2,4-dinitrophenyl and 1,2,3-triazole moieties as optical sensor for ammonia and chromium ions in water.

Authors:  Hanan A Mohamed; Bakr F Abdel-Wahab; Mahmoud N M Yousif; Reda M Abdelhameed
Journal:  BMC Chem       Date:  2022-04-07

5.  Theoretical and experimental investigation of anticancer activities of an acyclic and symmetrical compartmental Schiff base ligand and its Co(ii), Cu(ii) and Zn(ii) complexes.

Authors:  Lotfali Saghatforoush; Keyvan Moeini; Seyed Abolfazl Hosseini-Yazdi; Zahra Mardani; Alireza Hajabbas-Farshchi; Heather T Jameson; Shane G Telfer; J Derek Woollins
Journal:  RSC Adv       Date:  2018-10-17       Impact factor: 4.036

Review 6.  A review exploring biological activities of hydrazones.

Authors:  Garima Verma; Akranth Marella; Mohammad Shaquiquzzaman; Mymoona Akhtar; Mohammad Rahmat Ali; Mohammad Mumtaz Alam
Journal:  J Pharm Bioallied Sci       Date:  2014-04

7.  Synthesis and Evaluation of New Oxadiazole, Thiadiazole, and Triazole Derivatives as Potential Anticancer Agents Targeting MMP-9.

Authors:  Ahmet Özdemir; Belgin Sever; Mehlika Dilek Altıntop; Halide Edip Temel; Özlem Atlı; Merve Baysal; Fatih Demirci
Journal:  Molecules       Date:  2017-07-04       Impact factor: 4.411
  7 in total

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