| Literature DB >> 23141913 |
Nuria Aguilar1, Marta Mir, Pedro M Grima, Manel López, Victor Segarra, Laia Esteban, Imma Moreno, Nuria Godessart, Gema Tarrasón, Teresa Domenech, Dolors Vilella, Clara Armengol, Mònica Córdoba, Mar Sabaté, Daniel Casals, Maria Domínguez.
Abstract
Amido-1,3,4-thiadiazoles have been identified as a novel structural class of potent and selective sphingosine-1-phosphate receptor subtype 1 agonists. Starting from a micromolar HTS hit with the help of an in-house homology model, robust structural-activity relationships were developed to yield compounds with good selectivity and excellent in vivo efficacy in rat models.Entities:
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Year: 2012 PMID： 23141913 DOI： 10.1016/j.bmcl.2012.09.110
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823