| Literature DB >> 23141105 |
A J Ullmann1, M C Dolan, C A Sackal, E Fikrig, J Piesman, N S Zeidner.
Abstract
Prior exposure of vertebrate hosts to tick salivary proteins can induce specific immunity to tick infestation, as well as affording protection against tick-transmitted Borrelia burgdorferi infection in the mammalian host. Vaccination using an adenovirus expression system to deliver 4 tick salivary proteins (Ad-Salps) derived from Ixodes scapularis, Salp15, Salp25A, Salp25D, and Isac, was explored. Results indicate that vaccination with tick salivary proteins in an adenoviral vector can be used to modulate a Th1 response in the host and partially control spirochete load in immunized mice after infected tick challenge. Published by Elsevier GmbH.Entities:
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Year: 2012 PMID： 23141105 PMCID： PMC4306421 DOI： 10.1016/j.ttbdis.2012.08.006
Source DB: PubMed Journal: Ticks Tick Borne Dis ISSN： 1877-959X Impact factor: 3.744