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Literature DB >> 23139207

Realizing the clinical potential of cancer nanotechnology by minimizing toxicologic and targeted delivery concerns.

Sanjay Singh¹, Arati Sharma, Gavin P Robertson.

Abstract

Nanotechnology has the potential to make smart drugs that would be capable of targeting cancer but not normal cells and to load combinations of cooperating agents into a single nanosized particle to more effectively treat this disease. However, to realize the full potential of this technology, the negative aspects associated with these nanoparticles need to be overcome. This review discusses concerns in the field limiting realization of the full clinical potential of this technology, which are toxicity and targeted delivery. Strategies to overcome these hurdles are also reviewed, which could lead to attainment of the full clinical potential of this exciting technology. ©2012 AACR.

Entities: Chemical Disease Gene Species

Mesh：

Substances：
Antineoplastic Agents

Year: 2012 PMID： 23139207 PMCID： PMC3616627 DOI： 10.1158/0008-5472.CAN-12-1527

Source DB: PubMed Journal: Cancer Res ISSN： 0008-5472 Impact factor: 12.701

49 in total

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Authors: Rochelle R Arvizo; Oscar R Miranda; Daniel F Moyano; Chad A Walden; Karuna Giri; Resham Bhattacharya; J David Robertson; Vincent M Rotello; Joel M Reid; Priyabrata Mukherjee
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Review 10. A toxicologic review of quantum dots: toxicity depends on physicochemical and environmental factors.

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