Literature DB >> 23137534

Role of leukotriene B₄ receptor signaling in human preadipocyte differentiation.

Kae Hirata1, Kazufumi Katayama, Atsushi Nakajima, Kenji Takada, Yoshinori Kamisaki, Koichiro Wada.   

Abstract

We investigated the role of leukotriene B(4) (LTB(4))-leukotriene receptor (BLT) signaling in preadipocyte differentiation into mature adipocytes. Blockade of BLT signaling by treatment with lipoxygenase inhibitors, a BLT antagonist, and small interfering RNAs for BLTs in human and mouse preadipocytes isolated from adipose tissues showed acceleration of differentiation into mature adipocytes. DNA microarray analysis revealed regulation of transforming growth factor, beta-induced 68 kDa (TGFBI) expression through the BLT signaling pathway during adipocyte differentiation. Knockdown of TGFBI also showed acceleration of preadipocyte differentiation. The LTB(4)-BLT signaling pathway may negatively regulate preadipocyte differentiation via induction of TGFBI expression as a rate-limiting system to control adipocyte differentiation.
Copyright © 2012 Elsevier Inc. All rights reserved.

Entities:  

Mesh：

Substances：

Year:  2012        PMID： 23137534     DOI： 10.1016/j.bbrc.2012.10.110

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  6 in total

1.  Effects of arachidonic acid on the concentration of hydroxyeicosatetraenoic acids in culture media of mesenchymal stromal cells differentiating into adipocytes or osteoblasts.

Authors:  Antonio Casado-Díaz; Carlos Ferreiro-Vera; Feliciano Priego-Capote; Gabriel Dorado; María Dolores Luque-de-Castro; José Manuel Quesada-Gómez
Journal:  Genes Nutr       Date:  2013-12-14       Impact factor: 5.523

2.  Dietary Arachidonic Acid Has a Time-Dependent Differential Impact on Adipogenesis Modulated via COX and LOX Pathways in Grass Carp Ctenopharyngodon idellus.

Authors:  Jing-Jing Tian; Cai-Xia Lei; Hong Ji; Li-Qiao Chen; Zhen-Yu Du
Journal:  Lipids       Date:  2016-10-17       Impact factor: 1.880

Review 3.  Mammalian lipoxygenases and their biological relevance.

Authors:  Hartmut Kuhn; Swathi Banthiya; Klaus van Leyen
Journal:  Biochim Biophys Acta       Date:  2014-10-12

4.  Mice lacking PLAP-1/asporin counteracts high fat diet-induced metabolic disorder and alveolar bone loss by controlling adipose tissue expansion.

Authors:  Hiromi Sakashita; Satoru Yamada; Masaki Kinoshita; Tetsuhiro Kajikawa; Tomoaki Iwayama; Shinya Murakami
Journal:  Sci Rep       Date:  2021-03-02       Impact factor: 4.379

5.  Involvement of Visceral Adipose Tissue in Immunological Modulation of Inflammatory Cascade in Preeclampsia.

Authors:  Katsuhiko Naruse; Juria Akasaka; Aiko Shigemitsu; Taihei Tsunemi; Natsuki Koike; Chiharu Yoshimoto; Hiroshi Kobayashi
Journal:  Mediators Inflamm       Date:  2015-05-31       Impact factor: 4.711

6.  Up-Regulated MicroRNA-27b Promotes Adipocyte Differentiation via Induction of Acyl-CoA Thioesterase 2 Expression.

Authors:  Yuka Murata; Takashi Yamashiro; Takaomi Kessoku; Israt Jahan; Haruki Usuda; Tetsuya Tanaka; Takayuki Okamoto; Atsushi Nakajima; Koichiro Wada
Journal:  Biomed Res Int       Date:  2019-12-10       Impact factor: 3.411
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.