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Literature DB >> 23135512

A sirtuin link between metabolism and heart disease.

Abstract

The sirtuins (SIRTs) have gained preeminence for their roles in the response to caloric restriction and the regulation of aging and lifespan. A new study now identifies gene promoters that bind the transcription factor AP1 as targets for silencing by SIRT6, providing possible links between SIRT6 deficiency and dysregulation of insulin-like growth factor signaling, hypertrophic cardiomyopathy and heart failure (pages 1643-1650).

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 2012 PMID： 23135512 PMCID： PMC3638005 DOI： 10.1038/nm.2983

Source DB: PubMed Journal: Nat Med ISSN： 1078-8956 Impact factor: 53.440

12 in total

Review 1. FOXOs and sirtuins in vascular growth, maintenance, and aging.

Authors: Mark F Oellerich; Michael Potente
Journal: Circ Res Date: 2012-04-27 Impact factor: 17.367

2. SIRT6 deficiency results in severe hypoglycemia by enhancing both basal and insulin-stimulated glucose uptake in mice.

Authors: Cuiying Xiao; Hyun-Seok Kim; Tyler Lahusen; Rui-Hong Wang; Xiaoling Xu; Oksana Gavrilova; William Jou; David Gius; Chu-Xia Deng
Journal: J Biol Chem Date: 2010-09-16 Impact factor: 5.157

3. Hepatic-specific disruption of SIRT6 in mice results in fatty liver formation due to enhanced glycolysis and triglyceride synthesis.

Authors: Hyun-Seok Kim; Cuiying Xiao; Rui-Hong Wang; Tyler Lahusen; Xiaoling Xu; Athanassios Vassilopoulos; Guelaguetza Vazquez-Ortiz; Won-Il Jeong; Ogyi Park; Sung Hwan Ki; Bin Gao; Chu-Xia Deng
Journal: Cell Metab Date: 2010-09-08 Impact factor: 27.287

4. Activation of insulin-like growth factor II receptor induces mitochondrial-dependent apoptosis through G(alpha)q and downstream calcineurin signaling in myocardial cells.

Authors: Chun-Hsien Chu; Bor-Show Tzang; Li-Mien Chen; Chung-Jung Liu; Fuu-Jen Tsai; Chang-Hai Tsai; James A Lin; Wei-Wen Kuo; Da-Tian Bau; Chun-Hsu Yao; Chih-Yang Huang
Journal: Endocrinology Date: 2008-12-18 Impact factor: 4.736

5. SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin.

Authors: Eriko Michishita; Ronald A McCord; Elisabeth Berber; Mitomu Kioi; Hesed Padilla-Nash; Mara Damian; Peggie Cheung; Rika Kusumoto; Tiara L A Kawahara; J Carl Barrett; Howard Y Chang; Vilhelm A Bohr; Thomas Ried; Or Gozani; Katrin F Chua
Journal: Nature Date: 2008-03-12 Impact factor: 49.962

6. SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span.

Authors: Tiara L A Kawahara; Eriko Michishita; Adam S Adler; Mara Damian; Elisabeth Berber; Meihong Lin; Ron A McCord; Kristine C L Ongaigui; Lisa D Boxer; Howard Y Chang; Katrin F Chua
Journal: Cell Date: 2009-01-09 Impact factor: 41.582

7. SIRT6 protects against pathological damage caused by diet-induced obesity.

Authors: Yariv Kanfi; Victoria Peshti; Reuven Gil; Shoshana Naiman; Liat Nahum; Eran Levin; Noga Kronfeld-Schor; Haim Y Cohen
Journal: Aging Cell Date: 2009-12-28 Impact factor: 9.304

8. Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans.

Authors: Laura A Herndon; Peter J Schmeissner; Justyna M Dudaronek; Paula A Brown; Kristin M Listner; Yuko Sakano; Marie C Paupard; David H Hall; Monica Driscoll
Journal: Nature Date: 2002-10-24 Impact factor: 49.962

9. The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun.

Authors: Nagalingam R Sundaresan; Prabhakaran Vasudevan; Lei Zhong; Gene Kim; Sadhana Samant; Vishwas Parekh; Vinodkumar B Pillai; P V Ravindra; Madhu Gupta; Valluvan Jeevanandam; John M Cunningham; Chu-Xia Deng; David B Lombard; Raul Mostoslavsky; Mahesh P Gupta
Journal: Nat Med Date: 2012-10-21 Impact factor: 53.440

10. The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha.

Authors: Lei Zhong; Agustina D'Urso; Debra Toiber; Carlos Sebastian; Ryan E Henry; Douangsone D Vadysirisack; Alexander Guimaraes; Brett Marinelli; Jakob D Wikstrom; Tomer Nir; Clary B Clish; Bhavapriya Vaitheesvaran; Othon Iliopoulos; Irwin Kurland; Yuval Dor; Ralph Weissleder; Orian S Shirihai; Leif W Ellisen; Joaquin M Espinosa; Raul Mostoslavsky
Journal: Cell Date: 2010-01-22 Impact factor: 41.582

6 in total

1. Sirtuin 1 represses PKC-ζ activity through regulating interplay of acetylation and phosphorylation in cardiac hypertrophy.

Authors: Jingyan Li; Junying Huang; Jing Lu; Zhen Guo; Zhuoming Li; Hui Gao; Panxia Wang; Wenwei Luo; Sidong Cai; Yuehuai Hu; Kaiteng Guo; Luping Wang; Zhenzhen Li; Minghui Wang; Xiaolei Zhang; Peiqing Liu
Journal: Br J Pharmacol Date: 2018-12-09 Impact factor: 8.739