Literature DB >> 23135510

Protective immunity from a germinal center sanctuary.

Harriet L Robinson1, Rama Rao Amara.   

Abstract

A new study provides mechanistic insights into how live attenuated simian immunodeficiency virus (SIV) vaccines (LAVs) can protect monkeys from infection with pathogenic SIV. The authors show that replicating LAVs stimulate a protective immune response from a safe haven in the germinal centers of lymph nodes (pages 1673-1681).

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Year:  2012        PMID： 23135510     DOI： 10.1038/nm.2986

Source DB:  PubMed          Journal:  Nat Med        ISSN： 1078-8956            Impact factor:   53.440


  9 in total

Review 1.  HIV vaccine design: insights from live attenuated SIV vaccines.

Authors:  Wayne C Koff; Philip R Johnson; David I Watkins; Dennis R Burton; Jeffrey D Lifson; Kim J Hasenkrug; Adrian B McDermott; Alan Schultz; Timothy J Zamb; Rosanne Boyle; Ronald C Desrosiers
Journal:  Nat Immunol       Date:  2006-01       Impact factor: 25.606

Review 2.  Towards an HIV cure: a global scientific strategy.

Authors:  Steven G Deeks; Brigitte Autran; Ben Berkhout; Monsef Benkirane; Scott Cairns; Nicolas Chomont; Tae-Wook Chun; Melissa Churchill; Michele Di Mascio; Christine Katlama; Alain Lafeuillade; Alan Landay; Michael Lederman; Sharon R Lewin; Frank Maldarelli; David Margolis; Martin Markowitz; Javier Martinez-Picado; James I Mullins; John Mellors; Santiago Moreno; Una O'Doherty; Sarah Palmer; Marie-Capucine Penicaud; Matija Peterlin; Guido Poli; Jean-Pierre Routy; Christine Rouzioux; Guido Silvestri; Mario Stevenson; Amalio Telenti; Carine Van Lint; Eric Verdin; Ann Woolfrey; John Zaia; Françoise Barré-Sinoussi
Journal:  Nat Rev Immunol       Date:  2012-07-20       Impact factor: 53.106

3.  Spatial alterations between CD4(+) T follicular helper, B, and CD8(+) T cells during simian immunodeficiency virus infection: T/B cell homeostasis, activation, and potential mechanism for viral escape.

Authors:  Jung Joo Hong; Praveen K Amancha; Kenneth Rogers; Aftab A Ansari; Francois Villinger
Journal:  J Immunol       Date:  2012-03-02       Impact factor: 5.422

Review 4.  Follicular helper CD4 T cells (TFH).

Authors:  Shane Crotty
Journal:  Annu Rev Immunol       Date:  2011       Impact factor: 28.527

5.  Follicular dendritic cells and human immunodeficiency virus infectivity.

Authors:  S L Heath; J G Tew; J G Tew; A K Szakal; G F Burton
Journal:  Nature       Date:  1995-10-26       Impact factor: 49.962

6.  Protective effects of a live attenuated SIV vaccine with a deletion in the nef gene.

Authors:  M D Daniel; F Kirchhoff; S C Czajak; P K Sehgal; R C Desrosiers
Journal:  Science       Date:  1992-12-18       Impact factor: 47.728

7.  HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation.

Authors:  Nicolas Chomont; Mohamed El-Far; Petronela Ancuta; Lydie Trautmann; Francesco A Procopio; Bader Yassine-Diab; Geneviève Boucher; Mohamed-Rachid Boulassel; Georges Ghattas; Jason M Brenchley; Timothy W Schacker; Brenna J Hill; Daniel C Douek; Jean-Pierre Routy; Elias K Haddad; Rafick-Pierre Sékaly
Journal:  Nat Med       Date:  2009-06-21       Impact factor: 53.440

8.  GagCM9-specific CD8+ T cells expressing limited public TCR clonotypes do not suppress SIV replication in vivo.

Authors:  Lara Vojnov; Mauricio A Martins; Jorge R Almeida; Zachary Ende; Eva G Rakasz; Matthew R Reynolds; Enrique J Leon; Kim L Weisgrau; Benjamin J Burwitz; Joy M Folkvord; Marlon G Veloso de Santana; Patrícia C Costa Neves; Elizabeth Connick; Pamela J Skinner; Emma Gostick; David H O'Connor; Nancy A Wilson; Myrna C Bonaldo; Ricardo Galler; David A Price; Danny C Douek; David I Watkins
Journal:  PLoS One       Date:  2011-08-26       Impact factor: 3.240

9.  Lymph node T cell responses predict the efficacy of live attenuated SIV vaccines.

Authors:  Yoshinori Fukazawa; Haesun Park; Mark J Cameron; Francois Lefebvre; Richard Lum; Noel Coombes; Eisa Mahyari; Shoko I Hagen; Jin Young Bae; Marcelo Delos Reyes; Tonya Swanson; Alfred W Legasse; Andrew Sylwester; Scott G Hansen; Andrew T Smith; Petra Stafova; Rebecca Shoemaker; Yuan Li; Kelli Oswald; Michael K Axthelm; Adrian McDermott; Guido Ferrari; David C Montefiori; Paul T Edlefsen; Michael Piatak; Jeffrey D Lifson; Rafick P Sékaly; Louis J Picker
Journal:  Nat Med       Date:  2012-09-09       Impact factor: 53.440
  9 in total
  3 in total

1.  Optical clearing based cellular-level 3D visualization of intact lymph node cortex.

Authors:  Eunjoo Song; Howon Seo; Kibaek Choe; Yoonha Hwang; Jinhyo Ahn; Soyeon Ahn; Pilhan Kim
Journal:  Biomed Opt Express       Date:  2015-09-28       Impact factor: 3.732

2.  Strong TH1-biased CD4 T cell responses are associated with diminished SIV vaccine efficacy.

Authors:  Venkateswarlu Chamcha; Pradeep B J Reddy; Sunil Kannanganat; Courtney Wilkins; Sailaja Gangadhara; Vijayakumar Velu; Richard Green; G Lynn Law; Jean Chang; James R Bowen; Pamela A Kozlowski; Michelle Lifton; Sampa Santra; Traci Legere; Lynette S Chea; Lakshmi Chennareddi; Tianwei Yu; Mehul S Suthar; Guido Silvestri; Cynthia A Derdeyn; Michael Gale; Francois Villinger; Eric Hunter; Rama Rao Amara
Journal:  Sci Transl Med       Date:  2019-11-20       Impact factor: 17.956

3.  B cell follicle sanctuary permits persistent productive simian immunodeficiency virus infection in elite controllers.

Authors:  Yoshinori Fukazawa; Richard Lum; Afam A Okoye; Haesun Park; Kenta Matsuda; Jin Young Bae; Shoko I Hagen; Rebecca Shoemaker; Claire Deleage; Carissa Lucero; David Morcock; Tonya Swanson; Alfred W Legasse; Michael K Axthelm; Joseph Hesselgesser; Romas Geleziunas; Vanessa M Hirsch; Paul T Edlefsen; Michael Piatak; Jacob D Estes; Jeffrey D Lifson; Louis J Picker
Journal:  Nat Med       Date:  2015-01-19       Impact factor: 53.440
  3 in total

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