| Literature DB >> 23134659 |
Eric Turtle1, Nicholas Chow, Charles Yang, Sergio Sosa, Udo Bauer, Mitch Brenner, David Solow-Cordero, Wen-Bin Ho.
Abstract
Non-peptidic inhibitors of procollagen C-proteinase (PCP) were designed from substrate leads. Compounds were optimized for potency and selectivity, with N-substituted aryl sulfonamide hydroxamates having the best combination of these properties. Compounds 89 and 60 have IC(50) values of 10 and 80 nM, respectively, against PCP; excellent selectivity over MMP's 1, 2, and 9; and activity in cell-based collagen deposition assays.Entities:
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Year: 2012 PMID： 23134659 DOI： 10.1016/j.bmcl.2012.10.067
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823