BACKGROUND: The etiopathological role of human papilloma virus (HPV) in the causation of oral cancer is till a subject of speculation. METHODS: We used the technique of Southern blot hybridization to detect the presence of HPV types 16 & 18 in biopsy specimens from oral cancer and leukoplakia patients as well as normal oral mucosal biopsies. RESULTS: The prevalence of either HPV type 16 or 18 was found in 64.5% (29/45) of oral cancer, 40%(12/30) of leukoplakia and 20%(9/45) of normal oral mucosal biopsies. No association could be demonstrated between tobacco usage habits or a history of genital warts with HPV prevalence. CONCLUSION: A significant finding was that none of the oral cancer patients were negative for both: a history of tobacco usage as well as presence of HPV infection, on Southern blot hybridization.
BACKGROUND: The etiopathological role of human papilloma virus (HPV) in the causation of oral cancer is till a subject of speculation. METHODS: We used the technique of Southern blot hybridization to detect the presence of HPV types 16 & 18 in biopsy specimens from oral cancer and leukoplakiapatients as well as normal oral mucosal biopsies. RESULTS: The prevalence of either HPV type 16 or 18 was found in 64.5% (29/45) of oral cancer, 40%(12/30) of leukoplakia and 20%(9/45) of normal oral mucosal biopsies. No association could be demonstrated between tobacco usage habits or a history of genital warts with HPV prevalence. CONCLUSION: A significant finding was that none of the oral cancerpatients were negative for both: a history of tobacco usage as well as presence of HPV infection, on Southern blot hybridization.
Entities:
Keywords:
Human papilloma virus; Leukoplakia; Oral cancer
Authors: S M Schwartz; J R Daling; D R Doody; G C Wipf; J J Carter; M M Madeleine; E J Mao; E D Fitzgibbons; S Huang; A M Beckmann; J K McDougall; D A Galloway Journal: J Natl Cancer Inst Date: 1998-11-04 Impact factor: 13.506