Literature DB >> 23132580

The role of acetylation in the subcellular localization of an oncogenic isoform of translation factor eIF5A.

Muhammad Ishfaq1, Kazuhiro Maeta, Satoko Maeda, Toru Natsume, Akihiro Ito, Minoru Yoshida.   

Abstract

Mammalian cells express two isoforms of eIF5A, eIF5A1 and eIF5A2, but little is known about the function of eIF5A2. Here we report that eIF5A2 is reversibly acetylated at lysine-47. HDAC6 and SIRT2 were identified as the enzymes responsible for deacetylating eIF5A2. Analysis using acetylation-deficient mutants indicated that acetylation regulates the subcellular localization of eIF5A2.

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Year:  2012        PMID： 23132580     DOI： 10.1271/bbb.120620

Source DB:  PubMed          Journal:  Biosci Biotechnol Biochem        ISSN： 0916-8451            Impact factor:   2.043


  10 in total

Review 1.  The translation factor eIF5A and human cancer.

Authors:  Michael B Mathews; John W B Hershey
Journal:  Biochim Biophys Acta       Date:  2015-05-13

2.  Identification of a novel small molecule that inhibits deacetylase but not defatty-acylase reaction catalysed by SIRT2.

Authors:  Norio Kudo; Akihiro Ito; Mayumi Arata; Akiko Nakata; Minoru Yoshida
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2018-06-05       Impact factor: 6.237

3.  Knockdown of EIF5A2 inhibits the malignant potential of non-small cell lung cancer cells.

Authors:  Cheng Chen; Bojia Zhang; Shanshan Wu; Yongxiang Song; Jian Li
Journal:  Oncol Lett       Date:  2018-01-22       Impact factor: 2.967

4.  Critical review of non-histone human substrates of metal-dependent lysine deacetylases.

Authors:  Tasha B Toro; Terry J Watt
Journal:  FASEB J       Date:  2020-08-30       Impact factor: 5.191

Review 5.  Roles of eukaryotic initiation factor 5A2 in human cancer.

Authors:  Feng-wei Wang; Xin-yuan Guan; Dan Xie
Journal:  Int J Biol Sci       Date:  2013-10-12       Impact factor: 6.580

Review 6.  Recent insights into eukaryotic translation initiation factors 5A1 and 5A2 and their roles in human health and disease.

Authors:  Gao-Qi Wu; Yan-Ming Xu; Andy T Y Lau
Journal:  Cancer Cell Int       Date:  2020-04-29       Impact factor: 5.722

7.  Validation of the Slow Off-Kinetics of Sirtuin-Rearranging Ligands (SirReals) by Means of Label-Free Electrically Switchable Nanolever Technology.

Authors:  Matthias Schiedel; Herwin Daub; Aymelt Itzen; Manfred Jung
Journal:  Chembiochem       Date:  2020-01-22       Impact factor: 3.164

8.  Eukaryotic translation initiation factor 5A and its posttranslational modifications play an important role in proliferation and potentially in differentiation of the human enteric protozoan parasite Entamoeba histolytica.

Authors:  Ghulam Jeelani; Tomoyoshi Nozaki
Journal:  PLoS Pathog       Date:  2021-02-16       Impact factor: 6.823

9.  Control of immediate early gene expression by CPEB4-repressor complex-mediated mRNA degradation.

Authors:  Fabian Poetz; Svetlana Lebedeva; Johanna Schott; Doris Lindner; Uwe Ohler; Georg Stoecklin
Journal:  Genome Biol       Date:  2022-09-12       Impact factor: 17.906

Review 10.  Multiple Roles of SIRT2 in Regulating Physiological and Pathological Signal Transduction.

Authors:  Changhui Zhu; Xue Dong; Xiwei Wang; Yingying Zheng; Juanjuan Qiu; Yanling Peng; Jiajun Xu; Zhengbin Chai; Chunyan Liu
Journal:  Genet Res (Camb)       Date:  2022-08-29       Impact factor: 1.375
  10 in total

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