| Literature DB >> 23132282 |
Rania M Deranieh1, Miriam L Greenberg, Pierre-B Le Calvez, Maura C Mooney, Marie E Migaud.
Abstract
The synthesis of a series of carbohydrate-nucleotide hybrids, designed to be multisubstrate adducts mimicking myo-inositol 1-phosphate synthase first oxidative transition state, is reported. Their ability to inhibit the synthase has been assessed and results have been rationalised computationally to estimate their likely binding mode.Entities:
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Year: 2012 PMID： 23132282 PMCID： PMC4346228 DOI： 10.1039/c2ob26577j
Source DB: PubMed Journal: Org Biomol Chem ISSN： 1477-0520 Impact factor: 3.876