OBJECTIVE: We sought to determine whether 4000 IU/d (vs 2000 IU/d) of vitamin D during pregnancy is safe and improves maternal/neonatal 25-hydroxyvitamin D [25(OH)D] in a dose-dependent manner. STUDY DESIGN: A total of 257 pregnant women 12-16 weeks' gestation were enrolled. Randomization to 2000 vs 4000 IU/d followed 1-month run-in at 2000 IU/d. Participants were monitored for hypercalciuria, hypercalcemia, and 25(OH)D status. RESULTS:Maternal 25(OH)D (n = 161) increased from 22.7 ng/mL (SD 9.7) at baseline to 36.2 ng/mL (SD 15) and 37.9 ng/mL (SD 13.5) in the 2000 and 4000 IU groups, respectively. While maternal 25(OH)D change from baseline did not differ between groups, 25(OH)D monthly increase differed between groups (P < .01). No supplementation-related adverse events occurred. Mean cord blood 25(OH)D was 22.1 ± 10.3 ng/mL in 2000 IU and 27.0 ± 13.3 ng/mL in 4000 IU groups (P = .024). After controlling for race and study site, preterm birth and labor were inversely associated with predelivery and mean 25(OH)D, but not baseline 25(OH)D. CONCLUSION: Maternal supplementation with vitamin D 2000 and 4000 IU/d during pregnancy improved maternal/neonatal vitamin D status. Evidence of risk reduction in infection, preterm labor, and preterm birth was suggestive, requiring additional studies powered for these endpoints.
RCT Entities:
OBJECTIVE: We sought to determine whether 4000 IU/d (vs 2000 IU/d) of vitamin D during pregnancy is safe and improves maternal/neonatal 25-hydroxyvitamin D [25(OH)D] in a dose-dependent manner. STUDY DESIGN: A total of 257 pregnant women 12-16 weeks' gestation were enrolled. Randomization to 2000 vs 4000 IU/d followed 1-month run-in at 2000 IU/d. Participants were monitored for hypercalciuria, hypercalcemia, and 25(OH)D status. RESULTS: Maternal 25(OH)D (n = 161) increased from 22.7 ng/mL (SD 9.7) at baseline to 36.2 ng/mL (SD 15) and 37.9 ng/mL (SD 13.5) in the 2000 and 4000 IU groups, respectively. While maternal 25(OH)D change from baseline did not differ between groups, 25(OH)D monthly increase differed between groups (P < .01). No supplementation-related adverse events occurred. Mean cord blood 25(OH)D was 22.1 ± 10.3 ng/mL in 2000 IU and 27.0 ± 13.3 ng/mL in 4000 IU groups (P = .024). After controlling for race and study site, preterm birth and labor were inversely associated with predelivery and mean 25(OH)D, but not baseline 25(OH)D. CONCLUSION: Maternal supplementation with vitamin D 2000 and 4000 IU/d during pregnancy improved maternal/neonatal vitamin D status. Evidence of risk reduction in infection, preterm labor, and preterm birth was suggestive, requiring additional studies powered for these endpoints.
Authors: C A Reasner; J F Dunn; D A Fetchick; Y Liel; B W Hollis; S Epstein; J Shary; G R Mundy; N H Bell Journal: J Bone Miner Res Date: 1990-01 Impact factor: 6.741
Authors: Lisa M Bodnar; Janet M Catov; Joseph M Zmuda; Margaret E Cooper; Meredith S Parrott; James M Roberts; Mary L Marazita; Hyagriv N Simhan Journal: J Nutr Date: 2010-03-03 Impact factor: 4.798
Authors: Ilkka Laaksi; Juha-Petri Ruohola; Pentti Tuohimaa; Anssi Auvinen; Riina Haataja; Harri Pihlajamäki; Timo Ylikomi Journal: Am J Clin Nutr Date: 2007-09 Impact factor: 7.045
Authors: Shanna Nesby-O'Dell; Kelley S Scanlon; Mary E Cogswell; Cathleen Gillespie; Bruce W Hollis; Anne C Looker; Chris Allen; Cindy Doughertly; Elaine W Gunter; Barbara A Bowman Journal: Am J Clin Nutr Date: 2002-07 Impact factor: 7.045
Authors: D Fischer; A Schroer; D Lüdders; T Cordes; B Bücker; J Reichrath; M Friedrich Journal: Clin Exp Obstet Gynecol Date: 2007 Impact factor: 0.146
Authors: Stuart A Hamilton; Rebecca McNeil; Bruce W Hollis; Deborah J Davis; Joyce Winkler; Carolina Cook; Gloria Warner; Betty Bivens; Patrick McShane; Carol L Wagner Journal: Int J Endocrinol Date: 2010-12-09 Impact factor: 3.257
Authors: Giuseppe Saggese; Francesco Vierucci; Annemieke M Boot; Justyna Czech-Kowalska; Giovanna Weber; Carlos A Camargo; Eric Mallet; Margherita Fanos; Nick J Shaw; Michael F Holick Journal: Eur J Pediatr Date: 2015-04-02 Impact factor: 3.183
Authors: Heather H Burris; Linda J Van Marter; Thomas F McElrath; Patrik Tabatabai; Augusto A Litonjua; Scott T Weiss; Helen Christou Journal: Pediatr Res Date: 2013-10-11 Impact factor: 3.756
Authors: Paula M Frew; Diane S Saint-Victor; Margaret Brewinski Isaacs; Sonnie Kim; Geeta K Swamy; Jeanne S Sheffield; Kathryn M Edwards; Tonya Villafana; Ouda Kamagate; Kevin Ault Journal: Clin Infect Dis Date: 2014-12-15 Impact factor: 9.079
Authors: M Cetinkaya; F Cekmez; G Buyukkale; T Erener-Ercan; F Demir; T Tunc; F N Aydın; G Aydemir Journal: J Perinatol Date: 2014-08-07 Impact factor: 2.521
Authors: Jennifer Jao; Laura Freimanis; Marisa M Mussi-Pinhata; Rachel A Cohen; Jacqueline P Monteiro; Maria L Cruz; Rhoda S Sperling; Andrea Branch; George K Siberry Journal: Int J Gynaecol Obstet Date: 2015-04-11 Impact factor: 3.561