Literature DB >> 23131320

Parabens: a real hazard or a scare story?

Florence Castelain1, Michel Castelain.   

Abstract

Parabens belong to a family of preservatives that are widely used, particularly in the cosmetic, pharmaceutical and food industries. Four esters are commonly used: methyl, ethyl, propyl and butyl parabens. They are either used alone or, for better efficacy, in the form of a mixture. They have been the target of a media smear campaign since 2005. Several studies have failed to formally prove their alleged responsibility in the occurrence of breast cancer. At recommended concentrations, methyl and ethyl parabens have no hormonal effect in humans. Propyl and butyl parabens are still being investigated as regards their effects on fertility in men exposed during early childhood. Parabens are well-known for having weak sensitising properties and for their absence of toxicity whereas new substitution products, not as well-known, may lead to new cases of contact allergy.

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Year:  2012        PMID: 23131320     DOI: 10.1684/ejd.2012.1835

Source DB:  PubMed          Journal:  Eur J Dermatol        ISSN: 1167-1122            Impact factor:   3.328


  4 in total

1.  Contact dermatitis associated with preservatives: Retrospective analysis of North American Contact Dermatitis Group data, 1994 through 2016.

Authors:  Amber Reck Atwater; Amy J Petty; Beiyu Liu; Cynthia L Green; Jonathan I Silverberg; Joel G DeKoven; Donald V Belsito; Margo J Reeder; Denis Sasseville; James S Taylor; Howard I Maibach; Matthew J Zirwas; James G Marks; Kathryn A Zug; Joseph F Fowler; Melanie D Pratt; Vincent A DeLeo; Erin M Warshaw
Journal:  J Am Acad Dermatol       Date:  2021-02-09       Impact factor: 15.487

2.  Paraben levels in an urban community of Western Canada.

Authors:  Stephen J Genuis; Detlef Birkholz; Luke Curtis; Court Sandau
Journal:  ISRN Toxicol       Date:  2013-12-17

3.  Evaluation of the presence of allergens in children's products available for sale in a big city.

Authors:  Rosana Lazzarini; Mariana de Figueiredo Silva Hafner; Mayara Gomes Rangel
Journal:  An Bras Dermatol       Date:  2018-06       Impact factor: 1.896

4.  Exposure to Propylparaben During Pregnancy and Lactation Induces Long-Term Alterations to the Mammary Gland in Mice.

Authors:  Joshua P Mogus; Charlotte D LaPlante; Ruby Bansal; Klara Matouskova; Benjamin R Schneider; Elizabeth Daniele; Shannon J Silva; Mary J Hagen; Karen A Dunphy; D Joseph Jerry; Sallie S Schneider; Laura N Vandenberg
Journal:  Endocrinology       Date:  2021-06-01       Impact factor: 4.736

  4 in total

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