BACKGROUND: Dengue is an important cause of morbidity and mortality in tropical and subtropical regions of the world. In Thailand, there has been no detailed research on mortality in children in terms of duration of admission and associated complications in the cases that died. OBJECTIVE: To assess the burden of dengue in Thailand in 2010 and to analyze the complications in patients aged under 18 years who died. MATERIAL AND METHOD: The authors described the mortality and complications of dengue fever and dengue hemorrhagic fever in patients under 18 years old using the information from the Health Situation Analysis of the Thai Population 2010 Project. RESULTS: In 2010, the overall mortality of dengue in all age groups and in patients aged under 18 years were 0.3 and 0.6/ 100,000, respectively. The mortality rate was highest among children aged 6-12 years (0.8/100,000). Among the 8 children with dengue fever that died, the 2 most common complications were fluid electrolyte and acid-base imbalance and disseminated intravascular coagulation (DIC). The common complications among the 91 cases with dengue hemorrhagic fever that died included fluid electrolyte and acid-base imbalance, hepatic failure, respiratory failure, bacterial infection, DIC and renal failure. CONCLUSION: Early diagnosis, careful management of fluid therapy, awareness of hepatic and renal impairment and early treatment of co-infection should decrease mortality of dengue hemorrhagic fever
BACKGROUND: Dengue is an important cause of morbidity and mortality in tropical and subtropical regions of the world. In Thailand, there has been no detailed research on mortality in children in terms of duration of admission and associated complications in the cases that died. OBJECTIVE: To assess the burden of dengue in Thailand in 2010 and to analyze the complications in patients aged under 18 years who died. MATERIAL AND METHOD: The authors described the mortality and complications of dengue fever and dengue hemorrhagic fever in patients under 18 years old using the information from the Health Situation Analysis of the Thai Population 2010 Project. RESULTS: In 2010, the overall mortality of dengue in all age groups and in patients aged under 18 years were 0.3 and 0.6/ 100,000, respectively. The mortality rate was highest among children aged 6-12 years (0.8/100,000). Among the 8 children with dengue fever that died, the 2 most common complications were fluid electrolyte and acid-base imbalance and disseminated intravascular coagulation (DIC). The common complications among the 91 cases with dengue hemorrhagic fever that died included fluid electrolyte and acid-base imbalance, hepatic failure, respiratory failure, bacterial infection, DIC and renal failure. CONCLUSION: Early diagnosis, careful management of fluid therapy, awareness of hepatic and renal impairment and early treatment of co-infection should decrease mortality of dengue hemorrhagic fever
Authors: Luciano Pamplona de Góes Cavalcanti; Deborah Nunes de Melo Braga; Lívia Maria Alexandre da Silva; Marina Gondim Aguiar; Mariana Castiglioni; José Udevanier Silva-Junior; Fernanda Montenegro de Carvalho Araújo; Renata Allana da Costa Pereira; Danielle Lima Malta; Margarida Maria de Lima Pompeu Journal: Am J Trop Med Hyg Date: 2015-11-23 Impact factor: 2.345
Authors: Rafael Henrique Machado Sacramento; Deborah Nunes de Melo Braga; Franciane Fardin Sacramento; Fernanda Montenegro de Carvalho Araújo; Antônio Afonso Bezerra Lima; Margarida Maria de Lima Pompeu; Danielle Malta Lima; Luciano Pamplona de Góes Cavalcanti Journal: BMC Res Notes Date: 2014-11-27
Authors: Kay M Tomashek; Aidsa Rivera; Brenda Torres-Velasquez; Elizabeth A Hunsperger; Jorge L Munoz-Jordan; Tyler M Sharp; Irma Rivera; Dario Sanabria; Dianna M Blau; Renee Galloway; Jose Torres; Rosa Rodriguez; Javier Serrano; Carlos Chávez; Francisco Dávila; Janice Perez-Padilla; Esther M Ellis; Gladys Caballero; Laura Wright; Sherif R Zaki; Carmen Deseda; Edda Rodriguez; Harold S Margolis Journal: PLoS Negl Trop Dis Date: 2016-10-11