BACKGROUND: Reliable methods for estimating the incidence of human immunodeficiency virus (HIV) infection are needed to monitor the epidemic, identify at-risk populations, and evaluate HIV prevention strategies. We used a multifaceted approach to estimate HIV incidence in the HIV Prevention Trials Network (HPTN) 064 study. METHODS: The HPTN 064 study enrolled 2067 HIV-seronegative women and 32 HIV-seropositive women with no prior HIV infection diagnosis. Women were followed for up to 12 months. HIV incidence estimates were based on (1) detection of acute HIV infection, (2) documentation of HIV seroconversion, and (3) detection of recent HIV infection, using a multiassay algorithm (MAA). RESULTS: Two women had acute HIV infection at enrollment, 4 seroconverted, and 2 were identified as recently infected at enrollment using the MAA. The annual HIV incidence estimate based on acute infection at enrollment (2.52% [95% confidence interval {CI}, .17%-9.33%], using a 14-day window period) was higher than the estimate based on seroconversion (0.24% [95% CI, .07%-.62%]; P = .027). Incidence estimates obtained using the MAA at enrollment and at the end of study were 0.25% (95% CI, .03%-.93%) and 0.13% (95% CI, .006%-.76%), respectively. CONCLUSIONS: We detected a high frequency of acute infection at enrollment. Cross-sectional HIV incidence estimates obtained using the MAA were similar to the longitudinal estimate based on HIV seroconversion. CLINICAL TRIALS REGISTRATION: NCT00995176.
BACKGROUND: Reliable methods for estimating the incidence of human immunodeficiency virus (HIV) infection are needed to monitor the epidemic, identify at-risk populations, and evaluate HIV prevention strategies. We used a multifaceted approach to estimate HIV incidence in the HIV Prevention Trials Network (HPTN) 064 study. METHODS: The HPTN 064 study enrolled 2067 HIV-seronegative women and 32 HIV-seropositivewomen with no prior HIV infection diagnosis. Women were followed for up to 12 months. HIV incidence estimates were based on (1) detection of acute HIV infection, (2) documentation of HIV seroconversion, and (3) detection of recent HIV infection, using a multiassay algorithm (MAA). RESULTS: Two women had acute HIV infection at enrollment, 4 seroconverted, and 2 were identified as recently infected at enrollment using the MAA. The annual HIV incidence estimate based on acute infection at enrollment (2.52% [95% confidence interval {CI}, .17%-9.33%], using a 14-day window period) was higher than the estimate based on seroconversion (0.24% [95% CI, .07%-.62%]; P = .027). Incidence estimates obtained using the MAA at enrollment and at the end of study were 0.25% (95% CI, .03%-.93%) and 0.13% (95% CI, .006%-.76%), respectively. CONCLUSIONS: We detected a high frequency of acute infection at enrollment. Cross-sectional HIV incidence estimates obtained using the MAA were similar to the longitudinal estimate based on HIV seroconversion. CLINICAL TRIALS REGISTRATION: NCT00995176.
Authors: Oliver Laeyendecker; Ron Brookmeyer; Amy E Oliver; Caroline E Mullis; Kevin P Eaton; Amy C Mueller; Lisa P Jacobson; Joseph B Margolick; Joelle Brown; Charles R Rinaldo; Thomas C Quinn; Susan H Eshleman Journal: AIDS Res Hum Retroviruses Date: 2011-12-01 Impact factor: 2.205
Authors: Silvina Masciotra; J Steven McDougal; Jane Feldman; Patrick Sprinkle; Laura Wesolowski; S Michele Owen Journal: J Clin Virol Date: 2011-10-05 Impact factor: 3.168
Authors: Timothy D Mastro; Andrea A Kim; Timothy Hallett; Thomas Rehle; Alex Welte; Oliver Laeyendecker; Tom Oluoch; Jesus M Garcia-Calleja Journal: J HIV AIDS Surveill Epidemiol Date: 2010-01-01
Authors: Mark W Pandori; John Hackett; Brian Louie; Ana Vallari; Teri Dowling; Sally Liska; Jeffrey D Klausner Journal: J Clin Microbiol Date: 2009-06-17 Impact factor: 5.948
Authors: Oliver Laeyendecker; Ron Brookmeyer; Matthew M Cousins; Caroline E Mullis; Jacob Konikoff; Deborah Donnell; Connie Celum; Susan P Buchbinder; George R Seage; Gregory D Kirk; Shruti H Mehta; Jacquie Astemborski; Lisa P Jacobson; Joseph B Margolick; Joelle Brown; Thomas C Quinn; Susan H Eshleman Journal: J Infect Dis Date: 2012-11-05 Impact factor: 5.226
Authors: Susan H Eshleman; Leila Khaki; Oliver Laeyendecker; Estelle Piwowar-Manning; LeTanya Johnson-Lewis; Marla Husnik; Beryl Koblin; Thomas Coates; Margaret Chesney; Ana Vallari; Sushil G Devare; John Hackett Journal: J Acquir Immune Defic Syndr Date: 2009-09-01 Impact factor: 3.731
Authors: Matthew M Cousins; Jacob Konikoff; Oliver Laeyendecker; Connie Celum; Susan P Buchbinder; George R Seage; Gregory D Kirk; Richard D Moore; Shruti H Mehta; Joseph B Margolick; Joelle Brown; Kenneth H Mayer; Beryl A Koblin; Darrell Wheeler; Jessica E Justman; Sally L Hodder; Thomas C Quinn; Ron Brookmeyer; Susan H Eshleman Journal: J Clin Microbiol Date: 2013-10-23 Impact factor: 5.948
Authors: J Justman; M Befus; J Hughes; J Wang; C E Golin; A A Adimora; I Kuo; D F Haley; C Del Rio; W M El-Sadr; A Rompalo; S Mannheimer; L Soto-Torres; S Hodder Journal: AIDS Behav Date: 2015-07
Authors: Sally L Hodder; Jessica Justman; James P Hughes; Jing Wang; Danielle F Haley; Adaora A Adimora; Carlos Del Rio; Carol E Golin; Irene Kuo; Anne Rompalo; Lydia Soto-Torres; Sharon B Mannheimer; Letanya Johnson-Lewis; Susan H Eshleman; Wafaa M El-Sadr Journal: Ann Intern Med Date: 2013-01-01 Impact factor: 25.391
Authors: Stéphanie Blaizot; Andrea A Kim; Clement Zeh; Benjamin Riche; David Maman; Kevin M De Cock; Jean-François Etard; René Ecochard Journal: AIDS Res Hum Retroviruses Date: 2016-12-13 Impact factor: 2.205
Authors: Danielle F Haley; Carol Golin; Wafaa El-Sadr; James P Hughes; Jing Wang; Malika Roman Isler; Sharon Mannheimer; Irene Kuo; Jonathan Lucas; Elizabeth DiNenno; Jessica Justman; Paula M Frew; Lynda Emel; Anne Rompalo; Sarah Polk; Adaora A Adimora; Lorenna Rodriquez; Lydia Soto-Torres; Sally Hodder Journal: J Womens Health (Larchmt) Date: 2014-04-17 Impact factor: 2.681