Literature DB >> 23129230

Enzyme-responsive controlled release of covalently bound prodrug from functional mesoporous silica nanospheres.

Amirali Popat1, Benjamin P Ross, Jian Liu, Siddharth Jambhrunkar, Freddy Kleitz, Shi Zhang Qiao.   

Abstract

I want to break free: Mesoporous silica nanoparticles are functionalized with sulfasalazine (SZ; see scheme), a prodrug of 5-aminosalicylic acid (5-ASA) and sulfapyridine, to generate enzyme-responsive nanocarriers. In the presence of the colon-specific enzyme azo-reductase (orange), 5-ASA and sulfapyridine are efficiently released.
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Year:  2012        PMID： 23129230     DOI： 10.1002/anie.201206416

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  9 in total

1.  Real-Time Monitoring of ATP-Responsive Drug Release Using Mesoporous-Silica-Coated Multicolor Upconversion Nanoparticles.

Authors:  Jinping Lai; Birju P Shah; Yixiao Zhang; Letao Yang; Ki-Bum Lee
Journal:  ACS Nano       Date:  2015-04-15       Impact factor: 15.881

Review 2.  Reactive Oxygen Species-Regulating Strategies Based on Nanomaterials for Disease Treatment.

Authors:  Chenyang Zhang; Xin Wang; Jiangfeng Du; Zhanjun Gu; Yuliang Zhao
Journal:  Adv Sci (Weinh)       Date:  2020-12-20       Impact factor: 16.806

3.  Versatile fluorescence resonance energy transfer-based mesoporous silica nanoparticles for real-time monitoring of drug release.

Authors:  Jinping Lai; Birju P Shah; Eric Garfunkel; Ki-Bum Lee
Journal:  ACS Nano       Date:  2013-03-11       Impact factor: 15.881

Review 4.  Enzyme-responsive nanomaterials for controlled drug delivery.

Authors:  Quanyin Hu; Prateek S Katti; Zhen Gu
Journal:  Nanoscale       Date:  2014-11-07       Impact factor: 7.790

Review 5.  Mesoporous silica nanoparticles for stimuli-responsive controlled drug delivery: advances, challenges, and outlook.

Authors:  Yuanhui Song; Yihong Li; Qien Xu; Zhe Liu
Journal:  Int J Nanomedicine       Date:  2016-12-20

6.  Rapid Fluorescence Quenching Detection of Escherichia coli Using Natural Silica-Based Nanoparticles.

Authors:  S N Aisyiyah Jenie; Yuni Kusumastuti; Fransiska S H Krismastuti; Yovilianda M Untoro; Rizna T Dewi; Linar Z Udin; Nina Artanti
Journal:  Sensors (Basel)       Date:  2021-01-28       Impact factor: 3.576

Review 7.  Mesoporous Silica Particles as Drug Delivery Systems-The State of the Art in Loading Methods and the Recent Progress in Analytical Techniques for Monitoring These Processes.

Authors:  Katarzyna Trzeciak; Agata Chotera-Ouda; Irena I Bak-Sypien; Marek J Potrzebowski
Journal:  Pharmaceutics       Date:  2021-06-24       Impact factor: 6.321

8.  Yoctowells as a simple model system for the encapsulation and controlled release of bioactive molecules.

Authors:  Sheshanath V Bhosale; Sidhanath V Bhosale
Journal:  Sci Rep       Date:  2013       Impact factor: 4.379

9.  Multifunctional Magnetic Mesoporous Silica Nanoagents for in vivo Enzyme-Responsive Drug Delivery and MR Imaging.

Authors:  Erdong Li; Yanmei Yang; Guangyu Hao; Xuan Yi; Shaohua Zhang; Yue Pan; Bengang Xing; Mingyuan Gao
Journal:  Nanotheranostics       Date:  2018-05-23
  9 in total

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