Hariharan Raju1, Elijah R Behr. 1. Cardiovascular Sciences Research Centre, St George's University of London, London, UK.
Abstract
PURPOSE OF REVIEW: Unexplained sudden death and the sudden arrhythmic death syndrome (SADS) affect a small but significant proportion of young and apparently healthy individuals. This review revisits the causes underlying such deaths and the investigational strategies that identify surviving family who may be at risk. RECENT FINDINGS: Recent epidemiological data is available from case series or government records. The yield from familial cardiological evaluation for inherited conditions has been supported by additional small series. The greatest advance has come with molecular autopsy studies, which have utilized various methodologies and candidate genes to investigate SADS cases and their families. SUMMARY: The latest research replicates and extends the existing knowledge regarding epidemiology and familial evaluation of SADS, whilst genetic studies support a role for the molecular autopsy.
PURPOSE OF REVIEW: Unexplained sudden death and the sudden arrhythmic death syndrome (SADS) affect a small but significant proportion of young and apparently healthy individuals. This review revisits the causes underlying such deaths and the investigational strategies that identify surviving family who may be at risk. RECENT FINDINGS: Recent epidemiological data is available from case series or government records. The yield from familial cardiological evaluation for inherited conditions has been supported by additional small series. The greatest advance has come with molecular autopsy studies, which have utilized various methodologies and candidate genes to investigate SADS cases and their families. SUMMARY: The latest research replicates and extends the existing knowledge regarding epidemiology and familial evaluation of SADS, whilst genetic studies support a role for the molecular autopsy.
Authors: Alica M Goldman; Elijah R Behr; Christopher Semsarian; Richard D Bagnall; Sanjay Sisodiya; Paul N Cooper Journal: Epilepsia Date: 2016-01 Impact factor: 5.864
Authors: Koonlawee Nademanee; Hariharan Raju; Sofia V de Noronha; Michael Papadakis; Laurence Robinson; Stephen Rothery; Naomasa Makita; Shinya Kowase; Nakorn Boonmee; Vorapot Vitayakritsirikul; Samrerng Ratanarapee; Sanjay Sharma; Allard C van der Wal; Michael Christiansen; Hanno L Tan; Arthur A Wilde; Akihiko Nogami; Mary N Sheppard; Gumpanart Veerakul; Elijah R Behr Journal: J Am Coll Cardiol Date: 2015-11-03 Impact factor: 24.094
Authors: Hariharan Raju; James S Ware; Jonathan R Skinner; Paula L Hedley; Gavin Arno; Donald R Love; Christian van der Werf; Jacob Tfelt-Hansen; Bo Gregers Winkel; Marta C Cohen; Xinzhong Li; Shibu John; Sanjay Sharma; Steve Jeffery; Arthur A M Wilde; Michael Christiansen; Mary N Sheppard; Elijah R Behr Journal: BMC Cardiovasc Disord Date: 2019-07-23 Impact factor: 2.298
Authors: Elizabeth Davida Paratz; Luke Rowsell; Dominica Zentner; Sarah Parsons; Natalie Morgan; Tina Thompson; Paul James; Andreas Pflaumer; Christopher Semsarian; Karen Smith; Dion Stub; Andre La Gerche Journal: Open Heart Date: 2020-01-20