BACKGROUND/AIMS: Vitamin D deficiency is highly prevalent in obese children, and obese children tend to respond poorly to vitamin D supplementation. The objective of the study was to compare the response to vitamin D(3) supplementation (2,000 IU once daily for 12 weeks) between obese and non-obese Caucasian adolescents. METHODS: The study design was open label non-randomized. It was carried out at a single center. Eighteen obese adolescents (aged 12-18 years) and the same number of age-, gender- and season-matched non-obese adolescents received vitamin D(3) (2,000 IU/day) orally for 12 weeks. Total serum 25-hydroxyvitamin D [25(OH)D], parathyroid hormone, calcium and phosphorus were measured at baseline and at the end of the 12-week period. RESULTS: The mean baseline 25(OH)D level was higher in the non-obese compared to the obese subjects (mean 28.9 vs. 25.2 ng/ml; p = 0.029). The increment in 25(OH)D levels following vitamin D supplementation was significantly lower in the obese adolescents (mean change 5.8 vs. 9.8 ng/ml; p = 0.019). CONCLUSIONS: Higher doses of vitamin D are required to treat vitamin D deficiency in obese adolescents compared to their non-obese peers.
BACKGROUND/AIMS: Vitamin D deficiency is highly prevalent in obesechildren, and obesechildren tend to respond poorly to vitamin D supplementation. The objective of the study was to compare the response to vitamin D(3) supplementation (2,000 IU once daily for 12 weeks) between obese and non-obese Caucasian adolescents. METHODS: The study design was open label non-randomized. It was carried out at a single center. Eighteen obese adolescents (aged 12-18 years) and the same number of age-, gender- and season-matched non-obese adolescents received vitamin D(3) (2,000 IU/day) orally for 12 weeks. Total serum 25-hydroxyvitamin D [25(OH)D], parathyroid hormone, calcium and phosphorus were measured at baseline and at the end of the 12-week period. RESULTS: The mean baseline 25(OH)D level was higher in the non-obese compared to the obese subjects (mean 28.9 vs. 25.2 ng/ml; p = 0.029). The increment in 25(OH)D levels following vitamin D supplementation was significantly lower in the obese adolescents (mean change 5.8 vs. 9.8 ng/ml; p = 0.019). CONCLUSIONS: Higher doses of vitamin D are required to treat vitamin Ddeficiency in obese adolescents compared to their non-obese peers.
Authors: Michael F Holick; Ethel S Siris; Neil Binkley; Mary K Beard; Aliya Khan; Jennifer T Katzer; Richard A Petruschke; Erluo Chen; Anne E de Papp Journal: J Clin Endocrinol Metab Date: 2005-03-29 Impact factor: 5.958
Authors: Robert J Kuczmarski; Cynthia L Ogden; Shumei S Guo; Laurence M Grummer-Strawn; Katherine M Flegal; Zuguo Mei; Rong Wei; Lester R Curtin; Alex F Roche; Clifford L Johnson Journal: Vital Health Stat 11 Date: 2002-05
Authors: M K Thomas; D M Lloyd-Jones; R I Thadhani; A C Shaw; D J Deraska; B T Kitch; E C Vamvakas; I M Dick; R L Prince; J S Finkelstein Journal: N Engl J Med Date: 1998-03-19 Impact factor: 91.245
Authors: Giuseppe Saggese; Francesco Vierucci; Flavia Prodam; Fabio Cardinale; Irene Cetin; Elena Chiappini; Gian Luigi De' Angelis; Maddalena Massari; Emanuele Miraglia Del Giudice; Michele Miraglia Del Giudice; Diego Peroni; Luigi Terracciano; Rino Agostiniani; Domenico Careddu; Daniele Giovanni Ghiglioni; Gianni Bona; Giuseppe Di Mauro; Giovanni Corsello Journal: Ital J Pediatr Date: 2018-05-08 Impact factor: 2.638
Authors: Jennifer M Sacheck; Maria I Van Rompay; Elizabeth M Olson; Virginia R Chomitz; Elizabeth Goodman; Catherine M Gordon; Misha Eliasziw; Michael F Holick; Christina D Economos Journal: Clin Trials Date: 2014-10-27 Impact factor: 2.486
Authors: Rebecca J Moon; Sarah R Crozier; Elaine M Dennison; Justin H Davies; Sian M Robinson; Hazel M Inskip; Keith M Godfrey; Cyrus Cooper; Nicholas C Harvey Journal: Am J Clin Nutr Date: 2015-09-23 Impact factor: 7.045
Authors: Jennifer M Sacheck; Maria I Van Rompay; Virginia R Chomitz; Christina D Economos; Misha Eliasziw; Elizabeth Goodman; Catherine M Gordon; Michael F Holick Journal: J Clin Endocrinol Metab Date: 2017-12-01 Impact factor: 5.958
Authors: Jenneke E van Atteveld; Iris E Verhagen; Marry M van den Heuvel-Eibrink; Hanneke M van Santen; Inge M van der Sluis; Natascia Di Iorgi; Jill H Simmons; Leanne M Ward; Sebastian J C M M Neggers Journal: Cancer Med Date: 2021-06-08 Impact factor: 4.452