| Literature DB >> 23128386 |
Pierre Stallforth1, Stefan Matthies, Alexander Adibekian, Dennis G Gillingham, Donald Hilvert, Peter H Seeberger.
Abstract
A chemoenzymatic synthesis of sialic acid from inexpensive N-acetyl-D-glucosamine is described. In a three-step Wittig-protection-ozonolysis strategy manno-configured aldehydes are obtained. Treatment with oxaloacetate in the presence of macrophomate synthase affords the signature α-keto-γ-hydroxy acid moiety with high diastereoselectivity.Entities:
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Year: 2012 PMID： 23128386 DOI： 10.1039/c2cc37305j
Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222