Literature DB >> 23124759

Envelope diversity, characteristics of V3 region and predicted co-receptor usage of human immunodeficiency viruses infecting north Indians.

Raiees Andrabi1, Rajesh Kumar, Manju Bala, Ambili Nair, Prakash Ss, Vandana Kushwaha, Kalpana Luthra.   

Abstract

Subtypes of human immunodeficiency virus type 1 circulating in 21 north Indian patients were characterized based on the partial sequence of the gp120 envelope protein. A majority of viruses (85.7%, 18/21) were subtype C, while 14.3% (3/21) were subtype A. Sequence analysis revealed that the V3 region was highly conserved compared with V4 and V5. The predicted use of co-receptors indicated exclusive usage of R5, except for two subtype A viruses (AIIMS279 and AIIMS281). Our results demonstrate conservation within the V3 loop of subtype C viruses, and suggest the emergence of non-clade C viruses in the north Indian population.

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Year:  2012        PMID： 23124759     DOI： 10.1007/s12275-012-2136-z

Source DB:  PubMed          Journal:  J Microbiol        ISSN： 1225-8873            Impact factor:   3.422


  19 in total

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2.  Prevalence of HIV infection in risk groups in Tamilnadu, India.

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4.  Subtype-specific conservation of isoleucine 309 in the envelope V3 domain is linked to immune evasion in subtype C HIV-1 infection.

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Review 8.  GP120: target for neutralizing HIV-1 antibodies.

Authors:  Ralph Pantophlet; Dennis R Burton
Journal:  Annu Rev Immunol       Date:  2006       Impact factor: 28.527

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10.  Genetic analysis of HIV-1 Circulating Recombinant Form 02_AG, B and C subtype-specific envelope sequences from Northern India and their predicted co-receptor usage.

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  4 in total

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2.  Single genome amplification and standard bulk PCR yield HIV-1 envelope products with similar genotypic and phenotypic characteristics.

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3.  Cross-neutralizing anti-HIV-1 human single chain variable fragments(scFvs) against CD4 binding site and N332 glycan identified from a recombinant phage library.

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4.  Diverse HCV Strains And HIV URFS Identified Amongst People Who Inject Drugs In India.

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  4 in total

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