OBJECTIVES: We investigated serum brain-derived neurotrophin factor (BDNF), nerve growth factor (NGF), neurotrophin-3 (NTF3), neurotrophin-4 (NTF4) and the glial-derived neurotrophic factor (GDNF), in relation to ketamine efficacy, in bipolar depressed patients resistant to treatment with antidepressants. METHODS: Twenty-five patients (4 male, 21 female), aged 27-67 years, with bipolar depression, receiving mood-stabilizing medications, were studied. Antidepressants were discontinued for at least 7 days before single intravenous ketamine infusion (0.5 mg/kg body weight). Response to ketamine was defined as ≥ 50% reduction on 17-item Hamilton Depression Rating Scale (HDRS) after 1 week, and remission as HDRS score ≤ 7. Serum BDNF, NGF, NTF3, NTF4 and GDNF levels were estimated by enzyme-linked immunosorbent assay. RESULTS: There were 13 ketamine responders and 12 non-responders. The remission was obtained in eight and 12 patients after seven and 14 days, respectively. At baseline, there were no differences between responders and non-responders in any of the neurotrophins. Serum BDNF was significantly reduced after 7 days in non-responders. Serum NGF, NT3, NT4 and GDNF did not significantly change. CONCLUSIONS: The results confirm an antidepressant effect of ketamine infusion as an add-on to mood-stabilizing drugs in bipolar depression resistant to antidepressant treatment. They may also suggest a possible involvement of BDNF in this effect.
OBJECTIVES: We investigated serum brain-derived neurotrophin factor (BDNF), nerve growth factor (NGF), neurotrophin-3 (NTF3), neurotrophin-4 (NTF4) and the glial-derived neurotrophic factor (GDNF), in relation to ketamine efficacy, in bipolar depressedpatients resistant to treatment with antidepressants. METHODS: Twenty-five patients (4 male, 21 female), aged 27-67 years, with bipolar depression, receiving mood-stabilizing medications, were studied. Antidepressants were discontinued for at least 7 days before single intravenous ketamine infusion (0.5 mg/kg body weight). Response to ketamine was defined as ≥ 50% reduction on 17-item Hamilton Depression Rating Scale (HDRS) after 1 week, and remission as HDRS score ≤ 7. Serum BDNF, NGF, NTF3, NTF4 and GDNF levels were estimated by enzyme-linked immunosorbent assay. RESULTS: There were 13 ketamine responders and 12 non-responders. The remission was obtained in eight and 12 patients after seven and 14 days, respectively. At baseline, there were no differences between responders and non-responders in any of the neurotrophins. Serum BDNF was significantly reduced after 7 days in non-responders. Serum NGF, NT3, NT4 and GDNF did not significantly change. CONCLUSIONS: The results confirm an antidepressant effect of ketamine infusion as an add-on to mood-stabilizing drugs in bipolar depression resistant to antidepressant treatment. They may also suggest a possible involvement of BDNF in this effect.
Authors: Martin Le Nedelec; Paul Glue; Helen Winter; Chelsea Goulton; Lucy Broughton; Natalie Medlicott Journal: Drug Deliv Transl Res Date: 2018-06 Impact factor: 4.617
Authors: Nicolas D Iadarola; Mark J Niciu; Erica M Richards; Jennifer L Vande Voort; Elizabeth D Ballard; Nancy B Lundin; Allison C Nugent; Rodrigo Machado-Vieira; Carlos A Zarate Journal: Ther Adv Chronic Dis Date: 2015-05 Impact factor: 5.091
Authors: Xiaolu Zhang; Rawan S Alnafisah; Abdul-Rizaq A Hamoud; Rammohan Shukla; Robert E McCullumsmith; Sinead M O'Donovan Journal: Adv Neurobiol Date: 2021
Authors: André R Brunoni; Rodrigo Machado-Vieira; Carlos A Zarate; Erica L M Vieira; Leandro Valiengo; Isabela M Benseñor; Paulo A Lotufo; Wagner F Gattaz; Antonio L Teixeira Journal: Prog Neuropsychopharmacol Biol Psychiatry Date: 2014-08-27 Impact factor: 5.067