Literature DB >> 231236

Morphine presynaptically inhibits a ganglionic cholinergic synapse.

J C Bornstein, H L Fields.   

Abstract

The effects of morphine on synaptic transmission through the inferior mesenteric ganglion (IMG) were studied using intracellular recording techniques. Morphine produced a reversible, dose-dependent reduction in the quantal content of the synaptic potentials with little or no effect on quantal size or the properties of the ganglion cells. This effect of morphine was antagonized by naloxone suggesting the presence of specific preganglionic opiate receptors.

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Year:  1979        PMID： 231236     DOI： 10.1016/0304-3940(79)91532-5

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  5 in total

1.  Effect of opiates on transmitter release from visualized hypogastric boutons innervating the rat pelvic ganglia.

Authors:  D A Warren; N A Lavidis
Journal:  Br J Pharmacol       Date:  1996-08       Impact factor: 8.739

2.  Sites and mechanisms of actions of enkephalin in the feline parasympathetic ganglion.

Authors:  Y Katayama; S Nishi
Journal:  J Physiol       Date:  1984-06       Impact factor: 5.182

3.  The effect of opiates on the terminal nerve impulse and quantal secretion from visualized amphibian nerve terminals.

Authors:  N A Lavidis
Journal:  Br J Pharmacol       Date:  1995-06       Impact factor: 8.739

4.  The dependence of excitatory junction potential amplitude on the external calcium concentration in narcotic tolerant mouse vas deferens.

Authors:  R Einstein; N A Lavidis
Journal:  Br J Pharmacol       Date:  1984-12       Impact factor: 8.739

5.  Morphine and opioid peptides reduce inhibitory synaptic potentials in hippocampal pyramidal cells in vitro without alteration of membrane potential.

Authors:  G R Siggins; W Zieglgänsberger
Journal:  Proc Natl Acad Sci U S A       Date:  1981-08       Impact factor: 11.205
  5 in total

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