OBJECTIVE: To investigate the time from symptom onset to institutionalization in persons with young-onset dementia (YOD) and compare these findings with late-onset dementia (LOD), and to determine which factors predict institutionalization in persons with YOD compared with LOD. DESIGN/ SETTING: Longitudinal study of community-dwelling patients with YOD and LOD and their caregivers. PARTICIPANTS: A total of 226 patients with YOD and 102 with LOD and their informal caregivers were recruited through memory clinics and health care facilities. MEASUREMENTS: Cox proportional hazard models were used to relate covariates with time to institutionalization. The main outcome was time from symptom onset to institutionalization. Key predictors were cohort (YOD or LOD), neuropsychiatric symptoms, caregiver distress caused by neuropsychiatric symptoms, and caregivers' sense of competence (Short Sense of Competence Questionnaire total score). RESULTS: The time from symptom onset to institutionalization was nearly 9 years for patients with YOD compared with approximately 4 years for patients with LOD. In the YOD group, apathy significantly predicted time of institutionalization. Furthermore, the caregiver's competence in caring for the person with dementia significantly predicted institutionalization in both groups. CONCLUSIONS: Patients with YOD are cared for at home for a longer period than patients with LOD. The results of this study underline the importance of a timely diagnosis for these patients and their families to facilitate the initiation of appropriate care and support. Support programs aimed at enhancing the caregivers' sense of competence and ability to deal with neuropsychiatric symptoms, especially apathy, may postpone the institutionalization of the patient.
OBJECTIVE: To investigate the time from symptom onset to institutionalization in persons with young-onset dementia (YOD) and compare these findings with late-onset dementia (LOD), and to determine which factors predict institutionalization in persons with YOD compared with LOD. DESIGN/ SETTING: Longitudinal study of community-dwelling patients with YOD and LOD and their caregivers. PARTICIPANTS: A total of 226 patients with YOD and 102 with LOD and their informal caregivers were recruited through memory clinics and health care facilities. MEASUREMENTS: Cox proportional hazard models were used to relate covariates with time to institutionalization. The main outcome was time from symptom onset to institutionalization. Key predictors were cohort (YOD or LOD), neuropsychiatric symptoms, caregiver distress caused by neuropsychiatric symptoms, and caregivers' sense of competence (Short Sense of Competence Questionnaire total score). RESULTS: The time from symptom onset to institutionalization was nearly 9 years for patients with YOD compared with approximately 4 years for patients with LOD. In the YOD group, apathy significantly predicted time of institutionalization. Furthermore, the caregiver's competence in caring for the person with dementia significantly predicted institutionalization in both groups. CONCLUSIONS:Patients with YOD are cared for at home for a longer period than patients with LOD. The results of this study underline the importance of a timely diagnosis for these patients and their families to facilitate the initiation of appropriate care and support. Support programs aimed at enhancing the caregivers' sense of competence and ability to deal with neuropsychiatric symptoms, especially apathy, may postpone the institutionalization of the patient.
Authors: Jay L P Fieldhouse; Flora T Gossink; Thomas C Feenstra; Sterre C M de Boer; Afina W Lemstra; Niels D Prins; Femke Bouwman; Ted Koene; Hanneke F M Rhodius-Meester; Freek Gillissen; Charlotte E Teunissen; Wiesje M van der Flier; Philip Scheltens; Annemieke Dols; Everard G B Vijverberg; Yolande A L Pijnenburg Journal: J Alzheimers Dis Date: 2021 Impact factor: 4.472
Authors: Ans J M J Mulders; Sytse U Zuidema; Renée Leeuwis; Hans Bor; Frans R J Verhey; Raymond T C M Koopmans Journal: Int J Geriatr Psychiatry Date: 2019-04-29 Impact factor: 3.485
Authors: Sandra Schüssler; Julia Zuschnegg; Lucas Paletta; Maria Fellner; Gerald Lodron; Josef Steiner; Sandra Pansy-Resch; Lara Lammer; Dimitrios Prodromou; Sebastian Brunsch; Magdalena Holter; Lorenzo Carnevale; Silvia Russegger Journal: JMIR Res Protoc Date: 2020-02-03
Authors: Kerstin Köhler; Jan Dreyer; Iris Hochgraeber; Milena von Kutzleben; Christiane Pinkert; Martina Roes; Bernhard Holle Journal: BMJ Open Date: 2021-04-14 Impact factor: 2.692
Authors: Marie-Paule E van Engelen; Flora T Gossink; Lieke S de Vijlder; Jan R A Meursing; Philip Scheltens; Annemiek Dols; Yolande A L Pijnenburg Journal: J Alzheimers Dis Date: 2020 Impact factor: 4.472