Literature DB >> 23122863

A regio- and stereoselective 1,3-dipolar cycloaddition for the synthesis of new-fangled dispiropyrrolothiazoles as antimycobacterial agents.

Abdulrahman I Almansour1, Sadath Ali, Mohamed Ashraf Ali, Rusli Ismail, Tan Soo Choon, Velmurugan Sellappan, Karthi Keyan Elumalai, Suresh Pandian.   

Abstract

A series of dispiropyrrolothiazoles compounds were synthesized using 1,3-dipolar cycloaddition and were screened for antimycobacterial activity against Mycobacterium tuberculosis H(37)Rv and INH resistant M. tuberculosis strains. Two of them were showing good activity with MIC of less than 1 μM. Compound (5f) was found to be the most active with MIC of 0.210 and 8.312 μM respectively.
Copyright © 2012 Elsevier Ltd. All rights reserved.

Entities:  

Mesh：

Substances：

Year:  2012        PMID： 23122863     DOI： 10.1016/j.bmcl.2012.10.059

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  3 in total

Review 1.  Molecule Property Analyses of Active Compounds for Mycobacterium tuberculosis.

Authors:  Vadim Makarov; Elena Salina; Robert C Reynolds; Phyo Phyo Kyaw Zin; Sean Ekins
Journal:  J Med Chem       Date:  2020-04-20       Impact factor: 7.446

2.  Multicomponent synthesis of spiropyrrolidine analogues derived from vinylindole/indazole by a 1,3-dipolar cycloaddition reaction.

Authors:  Manjunatha Narayanarao; Lokesh Koodlur; Vijayakumar G Revanasiddappa; Subramanya Gopal; Susmita Kamila
Journal:  Beilstein J Org Chem       Date:  2016-12-29       Impact factor: 2.883

3.  Conformational analysis, molecular structure, spectroscopic, NBO, reactivity descriptors, wavefunction and molecular docking investigations of 5,6-dimethoxy-1-indanone: A potential anti Alzheimer's agent.

Authors:  S Sebastian; S Sylvestre; N Sundaraganesan; B Karthikeyan; S Silvan
Journal:  Heliyon       Date:  2022-01-23
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.