| Literature DB >> 23122859 |
Yusuke Oka1, Tetsuya Yabuuchi, Yasuyuki Fujii, Hidenori Ohtake, Shunichi Wakahara, Kayo Matsumoto, Mayumi Endo, Yunoshin Tamura, Yoshinori Sekiguchi.
Abstract
A novel series of 2-aminothiazole-oxazoles was designed and synthesized as part of efforts to develop potent phosphoinositide 3-kinase γ (PI3Kγ) inhibitors. The modification of a high-throughput screening hit, compound 1, resulted in the identification of compounds 10 and 15, which displayed potent inhibitory activities in enzyme-based and cell-based assays.Entities:
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Year: 2012 PMID： 23122859 DOI： 10.1016/j.bmcl.2012.10.028
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823