| Literature DB >> 23122858 |
Akiko Suganami1, Taro Toyota, Shigetoshi Okazaki, Kengo Saito, Katsuhiko Miyamoto, Yasunori Akutsu, Hiroshi Kawahira, Akira Aoki, Yutaka Muraki, Tomoyuki Madono, Hideki Hayashi, Hisahiro Matsubara, Takashige Omatsu, Hiroshi Shirasawa, Yutaka Tamura.
Abstract
We have rationally designed and synthesized a novel near-infrared (NIR) photoactivating probe, designated by iDOPE, in which an indocyanine green (ICG) fluorophore is covalently conjugated with a phospholipid moiety, 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE), to incorporate into liposome bilayers. NIR irradiation showed that iDOPE retained the optical and fluorescence properties of ICG and demonstrated photoactivator characteristics: fluorescence emission at around 820 nm in a solvent, singlet oxygen production, and concentration-dependent heat generation. Additionally, iDOPE was incorporated into liposome bilayers and maintained stable liposomally formulated iDOPE (LP-iDOPE) over 1week under physiological conditions. We also observed the tumor-specific biodistribution of LP-iDOPE of in vivo xenografts. These findings suggest that LP-iDOPE might be a promising tool for NIR optical imaging, photodynamic therapy, and photothermal therapy.Entities:
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Year: 2012 PMID： 23122858 DOI： 10.1016/j.bmcl.2012.10.044
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823