Literature DB >> 23122522

Discovery of di-indolinone as a novel scaffold for protein tyrosine phosphatase 1B inhibitors.

Hou-ling Dai1, Li-xin Gao, Ying Yang, Jing-ya Li, Jia-gao Cheng, Jia Li, Ren Wen, Yan-qing Peng, Jian-bin Zheng.   

Abstract

A series of di-indolinone derivatives was designed and synthesized to optimize our lead compounds basing on molecular docking study as PTP1B inhibitors. Successive enzymatic assay identified the synthetic di-indolinone as novel PTP1B inhibitors with low micromole-ranged inhibitory activity and at least several-fold selectivity over other tested homologous PTPs.
Copyright © 2012 Elsevier Ltd. All rights reserved.

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Year:  2012        PMID： 23122522     DOI： 10.1016/j.bmcl.2012.10.054

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  2 in total

Review 1.  Computational Methods in Cooperation with Experimental Approaches to Design Protein Tyrosine Phosphatase 1B Inhibitors in Type 2 Diabetes Drug Design: A Review of the Achievements of This Century.

Authors:  Mara Ibeth Campos-Almazán; Alicia Hernández-Campos; Rafael Castillo; Erick Sierra-Campos; Mónica Valdez-Solana; Claudia Avitia-Domínguez; Alfredo Téllez-Valencia
Journal:  Pharmaceuticals (Basel)       Date:  2022-07-14

2.  1H-2,3-dihydroperimidine derivatives: a new class of potent protein tyrosine phosphatase 1B inhibitors.

Authors:  Wen-Long Wang; Dong-Lin Yang; Li-Xin Gao; Chun-Lan Tang; Wei-Ping Ma; Hui-Hua Ye; Si-Qi Zhang; Ya-Nan Zhao; Hao-Jie Xu; Zhao Hu; Xia Chen; Wen-Hua Fan; Hai-Jun Chen; Jing-Ya Li; Fa-Jun Nan; Jia Li; Bainian Feng
Journal:  Molecules       Date:  2013-12-23       Impact factor: 4.411
  2 in total

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