OBJECTIVES: Patients with frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) may be agraphic. The study aimed at characterizing agraphia in individuals with a P301L MAPT mutation. METHODS: Two pairs of siblings with FTDP-17 were longitudinally examined for agraphia in relation to language and cognitive deficits. RESULTS: All patients presented with dysexecutive agraphia. In addition, in the first pair of siblings one sibling demonstrated spatial agraphia with less pronounced allographic agraphia and the other sibling had aphasic agraphia. Aphasic agraphia was also present in one sibling from the second pair. CONCLUSION: Agraphia associated with FTDP-17 is very heterogeneous.
OBJECTIVES:Patients with frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) may be agraphic. The study aimed at characterizing agraphia in individuals with a P301LMAPT mutation. METHODS: Two pairs of siblings with FTDP-17 were longitudinally examined for agraphia in relation to language and cognitive deficits. RESULTS: All patients presented with dysexecutive agraphia. In addition, in the first pair of siblings one sibling demonstrated spatial agraphia with less pronounced allographic agraphia and the other sibling had aphasic agraphia. Aphasic agraphia was also present in one sibling from the second pair. CONCLUSION:Agraphia associated with FTDP-17 is very heterogeneous.
Authors: A Alberici; C Gobbo; A Panzacchi; F Nicosia; R Ghidoni; L Benussi; C Hock; A Papassotiropoulos; P Liberini; J H Growdon; G B Frisoni; A Villa; O Zanetti; S Cappa; F Fazio; G Binetti Journal: J Neurol Neurosurg Psychiatry Date: 2004-11 Impact factor: 10.154
Authors: Bradley F Boeve; Ivo W Tremont-Lukats; Andrew J Waclawik; Jill R Murrell; Bruce Hermann; Clifford R Jack; Maria M Shiung; Glenn E Smith; Anil R Nair; Noralane Lindor; Vinaya Koppikar; Bernardino Ghetti Journal: Brain Date: 2004-12-22 Impact factor: 13.501
Authors: Zoe Arvanitakis; Robert J Witte; Dennis W Dickson; Yoshio Tsuboi; Ryan J Uitti; Jerzy Slowinski; Michael L Hutton; Siong-Chi Lin; Bradley F Boeve; William P Cheshire; Robert A Pooley; Julie M Liss; John N Caviness; Audrey J Strongosky; Zbigniew K Wszolek Journal: Parkinsonism Relat Disord Date: 2006-12-29 Impact factor: 4.891
Authors: D H Geschwind; J Robidoux; M Alarcón; B L Miller; K C Wilhelmsen; J L Cummings; Z S Nasreddine Journal: Ann Neurol Date: 2001-12 Impact factor: 10.422