J Mwita1, F Mugusi, K Pallangyo. 1. Department of Internal Medicine, Muhimbili University of Health and Allied Sciences, P.O. Box 65001, Dar Es Salaam, Tanzania. jmwita@gmail.com
Abstract
BACKGROUND: Respiratory infections such as pulmonary tuberculosis (PTB) and pneumonia are significant causes of morbidity and mortality in HIV infection. Recent studies have shown an increase in Pneumocystis jerovecii pneumonia (PCP) in Sub-Saharan Africa. This study determines the prevalence of PCP and other pulmonary infections among HIV patients at HIV clinics in Tanzania. METHODS: HIV infected patients with cough were enrolled between May and November 2006. Sputum induction was done and examined for PCP using Toluidine blue stain and Polymerase chain reaction. Ziehl-Neelsen stain was also done for PTB. RESULTS: Nine of the 125 (7.2%) had smear positive PTB. PCP was diagnosed in 10.4% (13/125) by Toluidine blue, while PCR was positive in 3.6% (3/88). Low CD4+ cell counts were associated with increased risk to both PCP and PTB. CONCLUSION: PCP is still low in Tanzania. PTB remains the major respiratory problem in HIV patients with cough. Toluidine blue staining is not reliable for PCP diagnosis
BACKGROUND:Respiratory infections such as pulmonary tuberculosis (PTB) and pneumonia are significant causes of morbidity and mortality in HIV infection. Recent studies have shown an increase in Pneumocystis jerovecii pneumonia (PCP) in Sub-Saharan Africa. This study determines the prevalence of PCP and other pulmonary infections among HIVpatients at HIV clinics in Tanzania. METHODS:HIV infectedpatients with cough were enrolled between May and November 2006. Sputum induction was done and examined for PCP using Toluidine blue stain and Polymerase chain reaction. Ziehl-Neelsen stain was also done for PTB. RESULTS: Nine of the 125 (7.2%) had smear positive PTB. PCP was diagnosed in 10.4% (13/125) by Toluidine blue, while PCR was positive in 3.6% (3/88). Low CD4+ cell counts were associated with increased risk to both PCP and PTB. CONCLUSION:PCP is still low in Tanzania. PTB remains the major respiratory problem in HIVpatients with cough. Toluidine blue staining is not reliable for PCP diagnosis
Authors: A Gupta; J Mbwambo; I Mteza; S Shenoi; B Lambdin; C Nyandindi; B I Doula; S Mfaume; R D Bruce Journal: Int J Tuberc Lung Dis Date: 2014-07 Impact factor: 2.373
Authors: Fiona Vanobberghen; Emilio Letang; Anna Gamell; Dorcas K Mnzava; Diana Faini; Lameck B Luwanda; Herry Mapesi; Kim Mwamelo; George Sikalengo; Marcel Tanner; Christoph Hatz; Hansjakob Furrer; Manuel Battegay; Tracy R Glass Journal: PLoS One Date: 2017-07-18 Impact factor: 3.240