OBJECTIVE: To determine the efficacy of intravenous dexamethasone in reducing postrhinoplasty edema. DESIGN: A prospective, randomized clinical trial with placebo control. SETTING: Department of Otorhinolaryngology, Al-Sabah and Zain Hospital, Kuwait. SUBJECT: Eighty-four patients (male = 28; female = 56) aged between 20 and 40 years, undergoing open rhinoplasty with hump removal and bilateral lateral osteotomies were enrolled in this study. INTERVENTION: Patients were randomized to receive two doses of 10 mg of dexamethasone intravenously or placebo, first dose during surgery and second dose 12 hours after surgery. MAIN OUTCOME MEASURES: Patients were evaluated postoperatively at 24 hours, days 2, 5, 7 and 10 for periorbital edema. RESULTS: 10 mg of dexamethasone given intravenously during rhinoplasty and a second dose 12 hours after surgery, reduced postoperative periorbital edema significantly. CONCLUSION: This study showed a statistically significant benefit of dexamethasone over placebo in reducing periorbital edema after rhinoplasty. No complications were attributed to the administration of dexamethasone.
RCT Entities:
OBJECTIVE: To determine the efficacy of intravenous dexamethasone in reducing postrhinoplasty edema. DESIGN: A prospective, randomized clinical trial with placebo control. SETTING: Department of Otorhinolaryngology, Al-Sabah and Zain Hospital, Kuwait. SUBJECT: Eighty-four patients (male = 28; female = 56) aged between 20 and 40 years, undergoing open rhinoplasty with hump removal and bilateral lateral osteotomies were enrolled in this study. INTERVENTION: Patients were randomized to receive two doses of 10 mg of dexamethasone intravenously or placebo, first dose during surgery and second dose 12 hours after surgery. MAIN OUTCOME MEASURES: Patients were evaluated postoperatively at 24 hours, days 2, 5, 7 and 10 for periorbital edema. RESULTS: 10 mg of dexamethasone given intravenously during rhinoplasty and a second dose 12 hours after surgery, reduced postoperative periorbital edema significantly. CONCLUSION: This study showed a statistically significant benefit of dexamethasone over placebo in reducing periorbital edema after rhinoplasty. No complications were attributed to the administration of dexamethasone.