Use of mitomycin C in endo-DCR.

OBJECTIVE: To evaluate the role of topical Mitomycin C in Endoscopic Dacryocystorhinostomy (DCR), for the prevention of stomal stenosis. PATIENTS: Thirty patients undergoing endoscopic DCR for chronic dacryocystitis were studied prospectively. The follow up period was 12 months. TECHNIQUE: PATIENTS were divided into two groups randomly. All of them underwent endoscopic DCR. One group was subjected to topical Mitomycin C application after surgery while the control group was not. MAIN OUTCOME MEASURES: Postoperative relief of epiphora and endoscopic documentation of the patency of the stoma were the main outcome measures.
RESULTS: 80% cases of the Mitomycin C group and 86.67% cases of the non Mitomycin C group had long-term successful results. This result is not statistically significant (p> 0.2).
CONCLUSION: Intraoperative Mitomycin C application does not alter the long-term results in endoscopic DCR. A properly and adequately performed surgery is more vital for successful result.

RCT Entities:   Population Interventions Outcomes