Effect of radiotherapy on serum mucoprotein level in carcinoma Larynx and Pharynx.

Serum mucoprotein level was determined in 61 individuals including 36 untreated patients of carcinoma Larynx & Pharynx and 25 healthy adults. Patients were treated by standard doses of radiation. Serum mucoprotein was again estimated following therapy. Patients showed a highly significant elevation in serum mucoprotein level as compared to controls (P<0.001). Radiotherapy caused a significant decline in the serum level of this biochemical (P<0.001). Stage of the disease had no correlation with the serum level of the mucoprotein. The dose of the radiation also had no relation with the decline in serum mucoprotein after irradiation. The fall in serum mucoprotein level was significantly higher in patients having complete response as compared to partial response (P<0.001), however there was no difference between the patients having partial response or no response.